Perspective targeted diagnosis and therapy of mitochondrial bioenergetics across different diagnoses.

Important metabolic variables that lead to the development of many diseases, including "mitochondrial diseases," include increased oxidative stress and mitochondrial malfunction. Given that the clinical picture and metabolic alterations in individuals suspected of having mitochondrial illnesses lack distinct characteristics, the development of sensitive and specific diagnostic techniques to detect alterations in mitochondrial bioenergetics is imperative. High-resolution respirometry (HRR), is a minimally invasive technique that enables the analysis of mitochondrial function in platelets taken from peripheral blood.

Platelet Mitochondrial Respiration, Endogenous Coenzyme Q and Oxidative Stress in Patients with Chronic Kidney Disease.

Unlabelled: Chronic kidney disease (CKD) is characterized by a progressive loss of renal function and a decrease of glomerular filtration rate. Reduced mitochondrial function, coenzyme Q (CoQ), and increased oxidative stress in patients with CKD contribute to the disease progression. We tested whether CoQ levels, oxidative stress and platelet mitochondrial bioenergetic function differ between groups of CKD patients.