ENDURAGen graft durability in α-Gal disease.

Purpose: We present a case of eyelid reconstruction using ENDURAGen, a porcine-derived acellular collagen graft, complicated by dissolution of the graft in a patient recently diagnosed with α-Gal disease.

Observations: A 33-year-old female status post enucleation of the left eye at age 7 struggling with malposition of her prosthesis due to lower lid retraction and laxity underwent eyelid reconstruction with ENDURAGen. She did well post-operatively for 9 months, but then began having issues with prosthesis dislodgement and rotation.

Effects of teprotumumab on patients with long-standing, active thyroid eye disease.

Purpose: Describe five cases of long-standing, active thyroid eye disease that responded to treatment with teprotumumab.

Observations: Five patients with a greater than 9-month-history of thyroid eye disease, including two patients who had previously failed orbital radiotherapy, received eight doses of teprotumumab. All five patients, including those with a history of orbital radiotherapy, achieved a proptosis reduction of at least 2 mm in each eye as well as a Clinical Activity Score reduction of at least 2 points.

IBRUTINIB FOR CONTROL OF CHOROIDAL AND ORBITAL METASTASIS FROM CHRONIC LYMPHOCYTIC LEUKEMIA.

Purpose: To describe a case of choroidal and orbital metastasis of chronic lymphocytic leukemia controlled with ibrutinib monotherapy, an oral tyrosine kinase inhibitor.

Methods: Single case report.

Results: A 69-year-old man with a past medical history of chronic lymphocytic leukemia diagnosed 1 year previously was referred with a foveal lesion in the right eye and was found to have hyperopic shift in the right eye.

Anatomic Features of Head and Neck Keratinocyte Cancer in Virginia.

Background: Keratinocyte cancer (KC) patients benefit from early diagnosis. We describe here the anatomy of head/neck KCs to help guide screening efforts.

Objective: To examine lesion frequency and anatomic distribution of head and neck KC.

Modified second stage Hughes tarsoconjunctival reconstruction for lower eyelid defects.

To describe a novel technique utilizing an amniotic membrane graft (AMT) to create the mucocutaneous portion of the lower eyelid margin in a modified Hughes eyelid reconstruction for secondary revision or prevention of a hyperemic, hypertrophic conjunctival margin with excessive discharge. This was a retrospective, non-comparative interventional study. Thirty consecutive patients who underwent a modified Hughes reconstruction were included.

Orbital mantle cell lymphoma presenting as myasthenia gravis.

A 69-year-old man, previously treated with pyridostigmine for myasthenia gravis (manifesting as ptosis and diplopia) was evaluated for several concomitant bilateral anterior orbital masses. Imaging revealed 3 discrete, solid masses within and around the orbits. An incisional biopsy demonstrated atypical lymphocytes positive for CD20 and Cyclin-D1, consistent with mantle cell lymphoma.

Pythium insidiosum: A Rare Necrotizing Orbital and Facial Infection.

Pythium insidiosum, also known as "swamp cancer," has been long known for its destructive effects on plants and animals. Infections with this fungus-like organism typically occur in temperate, tropical, and subtropical regions [ 1]. Human infection with P insidiosum, although exceedingly rare, is characterized by invasion of the cornea, cutaneous, subcutaneous, and orbital tissues with eosinophilic, tumor-like masses demonstrating arterial tropism [ 1, 2].

Anophthalmic syndrome: a review of management.

Purpose: To review and summarize current management of anophthalmic syndrome-enophthalmos, superior sulcus syndrome, lower eyelid laxity, and upper eyelid ptosis.

Methods: The authors performed a PubMed search of all articles published in English on the management of anophthalmic socket syndrome.

Results: A review of 37 articles demonstrated that anophthalmic syndrome occurs in a significant proportion of this patient population.

Pediatric anophthalmic sockets and orbital implants: outcomes with polymer-coated implants.

Purpose: To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies.

Design: Retrospective, interventional cohort study.

Participants: All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital.

Desmoplastic trichoepithelioma: report of a unique periocular case.

In a 58-year-old woman with blepharospasm, a slowly enlarging left inferomedial eyelid lesion developed. It measured 3 × 5 mm and was nonulcerated, well-circumscribed, whitish, upraised, and firm. An initial incomplete excision followed by a total repeated excision revealed small squamous microcysts, often exhibiting calcifications and cords of nonclefting basaloid cells embedded in a scirrhous stroma characteristic of desmoplastic trichoepithelioma (DTE).

Clinicopathologic and immunohistochemical features of pigmented Basal cell carcinomas of the eyelids.

Purpose: To describe the clinical and microscopic features of pigmented basal cell carcinomas (pBCC) of the eyelid.

Design: Retrospective observational case series collected at one institution.

Methods: An analysis of clinical records, photographs, and histopathologic characteristics of 257 BCCs with a review of the literature.

Ocular cicatricial pemphigoid: a review of clinical features, immunopathology, differential diagnosis, and current management.

Ocular cicatricial pemphigoid is a devastating autoimmune blistering disorder mainly affecting the conjunctiva but frequently associated with systemic mucosal findings. This article is an update of the pathogenesis, ocular findings, differential diagnosis, and approaches to treatment.

The effect of cancer therapies on pediatric anophthalmic sockets.

Purpose: To determine the impact of chemotherapy or external beam radiotherapy (EBRT) on pediatric anophthalmic sockets.

Design: A retrospective, nonrandomized, interventional cohort study.

Participants: A total of 135 sockets of 133 children undergoing enucleation from late 1999 to early 2009 at the St.

Focal blue nevus of the eyelid margin (mucocutaneous junction): a report of a unique case with a review of the literature.

Purpose: To describe the first isolated and focal benign blue nevus of the eyelid margin.

Methods: Review of clinical, histopathologic, and immunohistochemical characteristics and relevant literature.

Results: A 93-year-old Caucasian woman with a flat, irregular, and deeply pigmented black growth of the left upper eyelid margin of unknown duration underwent a full-thickness eyelid excisional biopsy.