Publications by Maria Kessler

Publications by authors named "Maria Kessler"

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Quantifying cell divisions along evolutionary lineages in cancer.

Martin Blohmer David M Cheek Wei-Ting Hung Maria Kessler Foivos Chatzidimitriou

Nat Genet

March 2025

Cell division drives somatic evolution but is challenging to quantify. We developed a framework to count cell divisions with DNA replication-related mutations in polyguanine homopolymers. Analyzing 505 samples from 37 patients, we studied the milestones of colorectal cancer evolution.

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