Publications by authors named "Maria Kerscher"
J Mol Med (Berl)
December 2014
Article Synopsis
- The study examined HLA class II molecules in various immune cells from cystic fibrosis (CF) patients and healthy individuals, revealing significantly lower HLA-DQ expression in CF patients, especially those in group 2 (average 1.24 ΔMnI).
- CF patients exhibited a sevenfold decrease in HLA-DQβ1 transcripts and a strong correlation between low HLA-DQ expression and elevated C-reactive protein (CRP) levels, suggesting an inflammation-related mechanism.
- In healthy individuals, interferon γ (IFNγ) could enhance HLA-DQ expression, but this response was impaired in CF, highlighting a potential deficiency in immune activation in these patients.
