Clonal diversity of clinical isolates producing NDM-type carbapenemase in Cuba, 2013-19.

Objectives: Our study aimed to elucidate the clonal diversity of carbapenem-resistant clinical isolates producing NDM-type carbapenemase collected through national surveillance in Cuba during a 7-year period (2013-19).

Methods: A total of 199 isolates of spp. from 37 hospitals in 12 provinces were genetically analyzed for their species, carbapenemase genes and genotypes.

A Retrospective Study of Risk Factors, Mortality, and Treatment Outcomes for Infections with Carbapenemase-Producing in a Tertiary Hospital in Havana, Cuba.

(1) Background: The spread of carbapenem-resistant Enterobacterales in hospitals constitutes an important epidemiological and therapeutic problem that especially affects vulnerable patients such as perioperative patients. (2) Methods: We conducted a descriptive, observational, retrospective case-control study of patients infected with carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) and carbapenem-susceptible Enterobacterales during the perioperative period in a tertiary hospital. (3) Results: Metallo-β-lactamase was detected in all 124 CRE isolates, with NDM-type carbapenemase being dominant, while 3 isolates coproduced KPC-type enzyme and showed high resistance rates against all antibiotics except colistin (25.

Community-Acquired Uropathogenic , Antimicrobial Susceptibility, and Extended-Spectrum Beta-Lactamase Detection.

Introduction: Urinary tract infection is the second-leading reason for consults in primary health care. Bacterial urinary tract infections are the most common, of which is the main etiologic agent. Antimicrobial resistance and multidrug resistance complicate effective community treatment, especially if resistance is caused by extended-spectrum beta-lactamase production.

Multicenter Study of Carbapenemase-Producing in Havana, Cuba, 2016-2021.

Surveillance of carbapenem resistance is particularly important for mainly in countries with limited healthcare resources. We conducted a cross-sectional study to detect carbapenem-resistant at 10 sentinel hospitals in Havana, Cuba for a six year-period (2016-2021) by the National Reference Laboratory for Health Care-Associated Infections in the Pedro Kourí Institute. A total of 152 isolates were collected with phenotypic production of metallo-β-lactamase.