Association between TMPRSS2:ERG fusion gene and the prostate cancer: systematic review and meta-analysis.

Introduction: To identify the association between the TMPRSS2:ERG fusion gene, their variants and the onset of localized prostate cancer.

Material And Methods: A systematic search strategy was carried out through MEDLINE, EMBASE, LILACS, CENTRAL and unpublished literature. We included randomized control trials, cohort, case-control and cross-sectional studies that involved patients >18 years-old assessing the association between TMPRSS2 fusion gene, its single nucleotide polymorphisms and prostate cancer.