Publications by authors named "Maria Jose Gattas"
Article Synopsis
- Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, with macrophages making up a significant portion of its cellular composition, and their interaction is crucial for tumor progression.
- A study was conducted to create a relevant culture model by investigating how U87MG GBM cells influence human monocytes, showing that these monocytes can differentiate into anti-inflammatory M2 macrophages in the presence of GBM factors.
- The findings indicate that both soluble factors from GBM and direct cell contact promote M2 macrophage differentiation within the tumor environment, which can aid in developing better therapies targeting these interactions.
The Tumor Microenvironment as a Regulator of Endocrine Resistance in Breast Cancer.
Front Endocrinol (Lausanne)
August 2019
Estrogen receptor positive breast neoplasias represent over 70% of diagnosed breast cancers. Depending on the stage at which the tumor is detected, HER2 status and genomic risk, endocrine therapy is combined with either radio, chemo and/or targeted therapy. A growing amount of evidence supports the notion that components of the tumor microenvironment play specific roles in response to treatment and that strategies targeting these key interactions with tumor cells could pave the way to a new generation of therapies.
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