Publications by authors named "Maria Jose Galazo"
Article Synopsis
- Selective motor neuron death remains a key concern in motor neuron disease research, particularly in spinal muscular atrophy (SMA), which is linked to low levels of the SMN protein.
- We found significant variation in SMN levels among motor neurons, not only in SMA but also in neurons from healthy individuals and ALS patients, indicating a broader relevance of SMN levels in neurodegenerative conditions.
- Low SMN levels correlate with increased susceptibility to cell death, suggesting that therapies aimed at elevating SMN may benefit multiple motor neuron diseases, as demonstrated by our finding that a specific enzyme inhibitor can enhance the survival of both SMA and ALS-derived motor neurons.
Reelin is a large secretable protein which is widely expressed by specific neuronal populations. In the embryonic brain, Reelin plays a signaling role critical for the correct positioning of migrating neuroblasts. Reelin is also expressed in the adult mammalian brain, including humans; however, its function/s there remain poorly understood.
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