Publications by authors named "Maria Jimena Ferraris"

Experimental autoimmune orchitis (EAO) is a chronic inflammatory disorder that causes progressive spermatogenic impairment. EAO is characterized by high intratesticular levels of nitric oxide (NO) and tumor necrosis factor alpha (TNFα) causing germ cell apoptosis and Sertoli cell dysfunction. However, the impact of this inflammatory milieu on the spermatogenic wave is unknown.

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Article Synopsis
  • Prolactin (PRL) and its receptor (PRLR) are present in glioblastoma multiforme (GBM), but their specific roles in the disease's development are not well understood.
  • When PRLR was activated or overexpressed in GBM cell lines, it led to increased cell growth and resistance to chemotherapy, while blocking PRLR reduced these abilities.
  • The study also found that male patients with high PRL/PRLR expression in GBM had worse survival outcomes, suggesting that PRLR could be a potential treatment target and highlights the importance of considering biological sex in GBM management.
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During an inflammatory process of the testis, the network of somatic, immune, and germ cell interactions is altered leading to organ dysfunction. In testicular biopsies of infertile men, spermatogenesis impairment is associated with reduced spermatogonia proliferation, increased number of immune cells, and content of pro-inflammatory cytokines. TNFα-TNFR and nitric oxide (NO)-NO synthase systems are up-regulated in models of testicular damage and in human testis with maturation arrest.

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