Publications by authors named "Maria Jesus Valle-Pastor"
Article Synopsis
- Enhancers like Eα can activate gene transcription by interacting with promoters over long distances within specific genomic regions called sub-topologically associated domains (sub-TADs).
- Eα regulates transcription across a 1-Mb region and exhibits variable activity in different T cell types, being inactive in some but necessary for high transcription levels in others.
- The study indicates that enhancers like Eα have distinct functional requirements depending on the genes they regulate, suggesting their roles are more complex than merely acting as connectors between DNA regions.
Int J Mol Sci
November 2020
Article Synopsis
- The adaptive immune response in vertebrates relies on specific antigen receptors in lymphocytes, with a key focus on the regulation of T-cell receptor (TCR) gene expression during thymocyte development.
- TCRs exist in unrearranged and rearranged forms, and proper rearrangement is essential for producing functional TCR chains that lead to the maturation of αβ and γδ T lymphocytes.
- The process involves 3D chromatin changes and enhancer activity that aid in V(D)J recombination, with distinct signaling pathways influencing how enhancers operate, ultimately regulating TCR gene expression during T-cell development.
