Publications by authors named "Maria Jesus Pareja-Megia"
Article Synopsis
- The study focused on patients with MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) and aimed to analyze the effects of different biochemical patterns (hepatocellular, mixed, and cholestatic) on liver damage, diagnostic accuracy, and prognosis.* -
- Results showed that the hepatocellular pattern had higher rates of liver inflammation, while the cholestatic pattern was more associated with cirrhosis; moreover, non-invasive tests were less accurate for detecting fibrosis in the hepatocellular pattern.* -
- The study highlighted that biochemical patterns largely remained consistent over time, with the cholestatic pattern linked to higher mortality risk, particularly in patients with age, diabetes, and cirrhosis.*
Background And Aim: Histological score systems may not fully capture the essential nonalcoholic steatohepatitis (NASH) features, which is one of the leading causes of screening failure in clinical trials. We assessed the NASH distribution and its components across the fibrosis stages and their impact on the prognosis and their relationship with the concept of metabolic-associated fatty liver disease (MAFLD).
Methods: Spanish multicenter study including 1893 biopsy-proven nonalcoholic fatty liver disease (NAFLD) patients from HEPAmet registry.
Urethral leiomyoma is a rare benign mesenchymal tumour arising from the smooth muscle of the urethra. It most often appears in females of reproductive age. Approximately 100 cases have been reported to date.
View Article and Find Full Text PDFBackground: Synchronous multiple primary malignancies in the female genital tract are infrequent. From 50 to 70% of them corresponds to synchronous cancers of the endometrium and ovary. To our knowledge, this is only the third case report in the international literature of three concurrent gynaecological cancers of epithelial origin.
View Article and Find Full Text PDFObjective: To identify markers of response to therapy in neuroblastic tumors.
Study Design: A total of 58 patients with neuroblastic tumor (38 neuroblastomas, 13 ganglioneuroblastomas and 7 ganglioneuromas) were included in the study. TP53, BCL-2, p21Waf1/Cip1 and metallothionein were included as a biologic approach to tumor differentiation, response to therapy and prognosis.
Background: Liposarcoma is a heterogeneous group of soft tissue sarcomas in which definitive prognostic parameters need to be identified.
Materials And Methods: The series included 33 consecutive soft tissue (well-differentiated, WDLPS, n=19; and dedifferentiated, DDLPS, n=14) liposarcoma. Clinicopathological variables included age, gender, body location, degree of dedifferentiation and mitotic count.
Whether TP53, BCL-2 and BAX expressions add independent prognostic information in patients with Ta/T1 bladder urothelial carcinoma remains unclear. TP53 overexpression correlated with high tumor grade (p=0.004), WHO grading categories (0.
View Article and Find Full Text PDFObjective: We report a case of a giant myelolipoma of the adrenal gland
Methods/results: A case of a giant myelolipoma of the adrenal gland, an uncommon non-functioning tumour of the adrenal cortex comprised of haematopoietic and adipose tissue, that had been detected incidentally during evaluation with CT because of its characteristic fatty composition. The clinical features, diagnosis and treatment are discussed.