Publications by authors named "Maria Jesus Giraldez-Fernandez"
Article Synopsis
- Cystinosis is a rare genetic disorder that leads to the buildup of cystine crystals, primarily affecting the kidneys and eyes, with severe ocular issues being a key concern.
- Currently, cysteamine is the only effective treatment for ocular symptoms, but its availability is limited due to pharmaceutical investment issues and stability problems, with two main marketed versions (Cystaran and Cystadrops).
- Research is focusing on developing new drug delivery systems like hydrogels, nanowafers, and contact lenses to enhance cysteamine administration and stability, aiming to improve patient adherence and explore future therapeutic options for cystinosis.
Objective: The sudden increase of blood flow in the bulbar conjunctiva, known as hyperemia, is associated to a red hue of variable intensity. Experts measure hyperemia using levels in a grading scale, a procedure that is subjective, non-repeatable and time consuming, thus creating a need for its automatisation. However, the task is far from straightforward due to data issues such as class imbalance or correlated features.
View Article and Find Full Text PDFPurpose: The lipid layer of the tear film limits evaporation during the interblink interval and also affects tear stability. This study was designed to validate a new software application designed to characterize the tear film lipid layer through texture and color pattern recognition.
Methods: Using the Tearscope-plus (slit-lamp magnification ×200), the lipid layer was examined in 105 healthy young adults, and interference photographs were acquired with a Topcon DV-3 digital camera.
Purpose: To assess the accuracy and repeatability of intraocular pressure (IOP) measurements obtained with the Canon TX-10 noncontact tonometer (NCT), using the Goldmann applanation tonometer (GAT) as the gold standard.
Methods: Seventy-three young healthy subjects were enrolled in the study. Central corneal thickness (CCT) was obtained with Orbscan Topography System and then repeated IOP measurements were obtained with both tonometers.
Purpose: This article compares measurements of corneal thickness obtained with the Orbscan Topography System with those obtained with the ultrasonic pachymeter, when used to measure central-comeal thickness in normal subjects.
Methods: Slit-scan topography (Orbscan II system, version 3.0, Bausch & Lomb, Rochester, NY) and ultrasonic pachymetry (Ophthasonic A-Scan/ Pachometer III, Accutome, Malvern, PA) were used to measure central-corneal thickness in 92 right corneas of 92 healthy adult subjects.