Recent Research in Ocular Cystinosis: Drug Delivery Systems, Cysteamine Detection Methods and Future Perspectives.

Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in different tissues and organs. Although renal damage prevails during initial stages, the deposition of cystine crystals in the cornea causes severe ocular manifestations. At present, cysteamine is the only topical effective treatment for ocular cystinosis.

On the development of conjunctival hyperemia computer-assisted diagnosis tools: Influence of feature selection and class imbalance in automatic gradings.

Objective: The sudden increase of blood flow in the bulbar conjunctiva, known as hyperemia, is associated to a red hue of variable intensity. Experts measure hyperemia using levels in a grading scale, a procedure that is subjective, non-repeatable and time consuming, thus creating a need for its automatisation. However, the task is far from straightforward due to data issues such as class imbalance or correlated features.

New software application for clarifying tear film lipid layer patterns.

Purpose: The lipid layer of the tear film limits evaporation during the interblink interval and also affects tear stability. This study was designed to validate a new software application designed to characterize the tear film lipid layer through texture and color pattern recognition.

Methods: Using the Tearscope-plus (slit-lamp magnification ×200), the lipid layer was examined in 105 healthy young adults, and interference photographs were acquired with a Topcon DV-3 digital camera.

Clinical evaluation of the Canon TX-10 noncontact tonometer in healthy eyes.

Purpose: To assess the accuracy and repeatability of intraocular pressure (IOP) measurements obtained with the Canon TX-10 noncontact tonometer (NCT), using the Goldmann applanation tonometer (GAT) as the gold standard.

Methods: Seventy-three young healthy subjects were enrolled in the study. Central corneal thickness (CCT) was obtained with Orbscan Topography System and then repeated IOP measurements were obtained with both tonometers.

A comparison of two pachymetric systems: slit-scanning and ultrasonic.

Purpose: This article compares measurements of corneal thickness obtained with the Orbscan Topography System with those obtained with the ultrasonic pachymeter, when used to measure central-comeal thickness in normal subjects.

Methods: Slit-scan topography (Orbscan II system, version 3.0, Bausch & Lomb, Rochester, NY) and ultrasonic pachymetry (Ophthasonic A-Scan/ Pachometer III, Accutome, Malvern, PA) were used to measure central-corneal thickness in 92 right corneas of 92 healthy adult subjects.