Validation and Comparison of Prognostic Models in Renal Carcinoma in a Tertiary Hospital.

Background: Renal cell carcinoma (RCC) is the third most frequent urological neoplasia. Proper risk stratification is essential for adequate management. Various calculators are available.

Prostate Cancer and the Mevalonate Pathway.

Antineoplastic therapies for prostate cancer (PCa) have traditionally centered around the androgen receptor (AR) pathway, which has demonstrated a significant role in oncogenesis. Nevertheless, it is becoming progressively apparent that therapeutic strategies must diversify their focus due to the emergence of resistance mechanisms that the tumor employs when subjected to monomolecular treatments. This review illustrates how the dysregulation of the lipid metabolic pathway constitutes a survival strategy adopted by tumors to evade eradication efforts.

Testosterone Recovery after Androgen Deprivation Therapy in Prostate Cancer: Building a Predictive Model.

Purpose: To analyze the variability, associated actors, and the design of nomograms for individualized testosterone recovery after cessation of androgen deprivation therapy (ADT).

Materials And Methods: A longitudinal study was carried out with 208 patients in the period 2003 to 2019. Castrated and normogonadic testosterone levels were defined as 0.

Using hyperrealistic simulations to improve digital informed consent for endourological procedures.

Objectives: To show that digital informed consent (DIC) improves the subjective understanding of information and, therefore, informed consent.

Patients And Methods: A nonblinded randomized controlled trial was performed in 84 patients who had undergone transurethral resection of bladder, transurethral resection of prostate, or ureterorenoscopy between July 2017 and March 2018. The DIC group watched a hyperrealistic simulation on a tablet device before surgery.

Teaching Urology to Undergraduates: A Prospective Survey of What General Practitioners Need to Know.

Background: Higher education training in Medicine has considerably evolved in recent years. One of its main goals has been to ensure the training of students as future adequately qualified general practitioners (GPs). Tools need to be developed to evaluate and improve the teaching of Urology at the undergraduate level.

[Usefulness of clinical nomograms and predictive models for pca. Predictive clinical factors of tumor agressiveness].

In this narrative review we present the natural evolution of predictive models to their presentation in the nomogram format. We show their clinical usefulness and the objective parameters that contribute to their clinical use: calibration, discrimination, decision curves and probability density functions. We continue detailing the various existing predictive models/nomograms in relation to prostate cancer aggressiveness before and after biopsy, before and after primary treatment, recurrence and castration resistance.

[Management of chylous fistulas, a rare complication after urologic surgery].

Objective: To analyze the different treatments for postoperative chylous fistulae.

Methods: A literature review of the main treatments for postoperative chylous fistula, providing our initial experience of two cases of patients with postsurgical chylorrea, with conservative treatment.

Results: There is very limited experience in the treatment of chylous ascites.

[Current validity of nomograms for prostate cancer staging].

Objective: [corrected] This paper presents a review of the concept of "nomogram" applied to prostate cancer, and specifically as a staging tool.

Methods/results: We describe the essential parameters for the evaluation of such type of predictive models: Calibration, discrimination and clinical usefulness. Such requisites are analyzed using a real clinical case in our clinical setting, comparing the "Partin's tables" and the "Miguel Servet University Hospital's nomogram".

[Current value of seminal vesicle biopsy in patients with prostate cancer and influence of radical prostatectomy in patients with seminal vesicle invasion].

Objectives: To evaluate if radical prostatectomy may positively influence cancer-specific survival (CSS), hormone-resistance-free time, metastasis-free time, and quality of life(QoL) of patients with prostate adenocarcinoma and seminal vesicle invasion, and also to update our thoughts about seminal vesicle biopsy.

Methods: 114 patients were included. Forty-six cases were diagnosed of seminal vesicle invasion after radical prostatectomy; 68 cases were diagnosed of seminal vesicle invasion after biopsy, not undergoing then surgery.

Controversies related to epithelioid variant of renal angiomyolipoma: a review of the literature.

We performed a review of the epithelioid-type angiomas to determine their clinical course and propose an appropriate plan for follow-up. We present the case of a patient with possible adrenal carcinoma suggested by computed tomography for whom the histopathologic study revealed an epithelioid angiomyolipoma arising from the kidney. In the absence of consensus, we consider it worthwhile to register the very few cases diagnosed and record a detailed follow-up of the clinical course.