Publications by authors named "Maria Jesus Del Valle-Pastor"
Int J Mol Sci
November 2020
Article Synopsis
- The adaptive immune response in vertebrates relies on specific antigen receptors in lymphocytes, with a key focus on the regulation of T-cell receptor (TCR) gene expression during thymocyte development.
- TCRs exist in unrearranged and rearranged forms, and proper rearrangement is essential for producing functional TCR chains that lead to the maturation of αβ and γδ T lymphocytes.
- The process involves 3D chromatin changes and enhancer activity that aid in V(D)J recombination, with distinct signaling pathways influencing how enhancers operate, ultimately regulating TCR gene expression during T-cell development.
