Polymorphisms of and Genes in Ovarian Cancer and Treatment Response in Poles.

Background/aim: Ovarian cancer is a lethal gynecological malignancy, with 5-year survival of only about one third of patients. The ABCB1 gene encodes the P-glycoprotein which is one of the multidrug efflux pumps. Its decreased activity may result in multidrug resistance of cancer cells.

Vertebroplasty with methacrylate bone cement and radiotherapy in the treatment of spinal metastases with epidural spinal cord compression. Preliminary report.

Background. The choice of treatment method for metastases to the spine remains an unresolved and controversial question. The major complication in disseminated neoplastic disease compression of the spine and nervous elements.

Mcm-2 protein expression predicts prognosis better than Ki-67 antigen in oral cavity squamocellular carcinoma.

Background: The present study aimed at evaluating the expression intensities of the Mcm-2 protein and Ki-67 antigen in squamocellular carcinomas of the oral cavity and comparing their prognostic value.

Materials And Methods: Forty-nine patients, operated on and treated with radiotherapy for carcinoma of the oral cavity floor and/or the mobile part of the tongue, were retrospectively analyzed.

Results: A significant positive correlation was noted between the expression of Mcm-2 protein and that of the Ki-67 antigen, as well as an absence of such correlations with the remaining examined factors.

[Assessment of hematopoiesis regeneration in patients with solid tumors after radiotherapy].

The myelotoxicity is one of the most severe adverse events of radiotherapy. Increase of CD34+ cells level in peripheral blood as result of raised output of granulocyte colony stimulating factor (G-CSF) can be result of hematopoiesis regeneration after radiotherapy. The aim of this study was to determine the hematopoiesis regeneration using analysis of CD34+ cells level in peripheral blood and serum concentration of G-CSF in patients treated with radiotherapy according to irradiated body region and irradiation field size.