Effect of orthodontic premolar extraction on maxillary teeth angulation and arch dimensions in adolescent patients: A 3-D digital model analysis.

Background: Therapeutic orthodontic premolar extraction is a common orthodontic treatment, yet the extent of its impact on the upper dental arch dimensions and teeth angulations is still under exploration. Hypothesis: We postulated that the therapeutic extraction of orthodontic premolars significantly alters the orientation of teeth and the dimensions of the dental arch. Objective: This study assessed the impact of therapeutic orthodontic premolar extraction on dental arch dimensions and tooth angulations.

Craniofacial and three-dimensional palatal analysis in cleft lip and palate patients treated in Spain.

Growth alterations have been described in patients operated on for oral clefts. The purpose of this work was to analyze the craniofacial and palate morphology and dimensions of young adults operated on for oral clefts in early childhood in Spain. Eighty-three patients from eight different hospitals were divided into four groups based on their type of cleft: cleft lip (CL, n = 6), unilateral cleft lip and palate (UCLP, n = 37), bilateral cleft lip and palate (BCLP, n = 16), and cleft palate only (CPO, n = 24).

CBCT and CAD-CAM technology to design a minimally invasive maxillary expander.

Background: A large number of articles in recent years studying the effects of non-surgically assisted tooth- versus bone-borne maxillary expanders in growing patients have found no significant differences in mid-palatal suture disjunction or even dentoalveolar changes. This suggests the need for new criteria and better use of current technology to make more effective devices and enhance the benefits of conventional treatments. This article describes a titanium grade V computer-aided design/computer-aided manufacturing (CAD/CAM) maxillary expander supported by two miniscrews, along with a 3D printed surgical guide.

Comparative study of nasopharyngeal soft-tissue characteristics in patients with Class III malocclusion.

Introduction: The aims of our study were to assess nasopharyngeal soft-tissue characteristics in white patients with Class III malocclusion and to compare the results with patients with ideal occlusion.

Methods: A sample of 71 patients with Class III malocclusion was selected from the Dental School at the Complutense University of Madrid. None of the subjects had a history of upper airway disease, adenoidectomy, or pathology in the pharynx.

Benzo[b]thiophene-6-carboxamide 1,1-dioxides: inhibitors of human cancer cell growth at nanomolar concentrations.

Benzo[b]thiophenesulfonamide 1,1-dioxide derivatives (BTS) were described as candidate antineoplastic drugs. In the hope of finding new compounds with improved antitumour activity and reduced toxicity, we have designed and synthesized a small series of benzo[b]thiophene-6-carboxamide 1,1-dioxide derivatives (BTC) structurally related with the best reported BTS. Growth inhibition of HTB-54, CCRF-CEM and HeLa tumour cells lines at nanomolar concentrations was exhibited by some of the BTC.