Publications by authors named "Maria J Stangou"
Galactose (Gal)-deficient IgA1 (Gd-IgA1) is involved in IgA nephropathy (IgAN) pathogenesis. To reflect racial differences in clinical characteristics, we assessed disease- and race-specific heterogeneity in the -glycosylation of the IgA1 hinge region (HR). We determined serum Gd-IgA1 levels in Caucasians (healthy controls [HCs], n = 31; IgAN patients, n = 63) and Asians (HCs, n = 20; IgAN patients, n = 60) and analyzed profiles of serum IgA1 HR -glycoforms.
View Article and Find Full Text PDFAim: Accumulating evidence supports the use of antineutrophil cytoplasmic antibody (ANCA) type to classify different clinical entities. We aimed to evaluate whether the presence and type of ANCA determine different diseases, based on clinical phenotypes, renal involvement, and response to treatment.
Patients And Methods: Differences in terms of clinical manifestations, disease activity, laboratory parameters, and histology were recorded between patients with focal necrotizing glomerulonephritis (FNGN) due to myeloperoxidase (MPO-), proteinase 3-ANCA(+) [PR3-ANCA(+)], and ANCA(-) disease at time of diagnosis.
Article Synopsis
- The study looked at how to diagnose and treat a kidney disease called primary membranous nephropathy (PMN) by examining specific features in kidney samples.
- Researchers analyzed the samples from 752 patients to see how conditions like focal segmental sclerosis (FSGS) and tubular atrophy (TA) affected kidney health.
- They found that certain conditions in the kidneys could predict how well they would function and help decide if patients needed special immune-suppressing treatments.