Publications by authors named "Maria J Roman"

Two new species of the Chilean endemic genus (Gilliesieae, Allioideae, Amaryllidaceae) are described, and , alongside morphological descriptions, a distribution map, illustrations, conservation status assessments, and an updated key to all species of . Additionally, phylogenetic analyses of DNA sequences were performed to inquire into the evolutionary affinities of both new species and the recently described, , within the tribe Gilliesieae.

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Changes in the transcription factor (TF) expression are critical for brain development, and they may also underlie neurodevelopmental disorders. Indeed, T-box brain1 (Tbr1) is a TF crucial for the formation of neocortical layer VI, and mutations and microdeletions in that gene are associated with malformations in the human cerebral cortex, alterations that accompany autism spectrum disorder (ASD). Interestingly, Tbr1 upregulation has also been related to the occurrence of ASD-like symptoms, although limited studies have addressed the effect of increased Tbr1 levels during neocortical development.

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Article Synopsis
  • The study assessed the effectiveness of one-step nucleic acid amplification (OSNA) compared to traditional pathological ultrastaging for detecting sentinel lymph node metastasis in early-stage endometrial cancer patients.
  • A total of 526 sentinel lymph nodes from 191 patients were analyzed, revealing that OSNA identified metastasis in 19.7% of cases, while ultrastaging detected it in only 8.8%.
  • OSNA demonstrated high sensitivity (92%) and resulted in a reclassification of disease stage for some patients, highlighting its potential to better determine the need for additional treatment upon diagnosis.
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Background: Cah3 is the only carbonic anhydrase (CA) isoform located in the thylakoid lumen of Chlamydomonas reinhardtii. Previous studies demonstrated its association with the donor side of the photosystem II (PSII) where it is required for the optimal function of the water oxidizing complex. However this enzyme has also been frequently proposed to perform a critical function in inorganic carbon acquisition and CO(2) fixation and all mutants lacking Cah3 exhibit very poor growth after transfer to low CO(2) conditions.

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Cumulative evidence indicates that activation of cyclin D-dependent kinase 4/6 (cdk4/6) represents a major trigger of cell cycle reentry and apoptosis in vertebrate neurons. We show here the existence of another mechanism triggering cell cycle reentry in differentiating chick retinal neurons (DCRNs), based on phosphorylation of E2F4 by p38(MAPK). We demonstrate that the activation of p75(NTR) by nerve growth factor (NGF) induces nuclear p38(MAPK) kinase activity, which leads to Thr phosphorylation and subsequent recruitment of E2F4 to the E2F-responsive cdc2 promoter.

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Background: The lack of adequate instruments prevents the possibility of assessing the competence of health care staff in evidence-based decision making and further, the identification of areas for improvement with tailored strategies. The aim of this study is to report about the validation process in the Spanish context of the Evidence-Based Practice Questionnaire (EBPQ) from Upton y Upton.

Methods: A multicentre, cross-sectional, descriptive psychometric validation study was carried out.

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