Voltammetry assisted by multivariate analysis as a tool for speciation of metallothioneins: competitive complexation of alpha- and beta-metallothionein domains with cadmium and zinc.

Multivariate Curve Resolution by Alternating Least Squares (MCR-ALS) is applied to voltammetric data obtained in the study of competitive complexation of Zn(II) and Cd(II) by alpha- and beta-domains of metallothionein (MT). The application of MCR-ALS allows the estimation of both the voltammograms and the concentration profiles associated with each electrochemical process. The complexity of the voltammograms obtained in titrations of the alpha- or beta-domains of MT with Cd(II) and later Zn(II) (or vice versa) prevents their direct interpretation using traditional electrochemical methods.

Visual field defects in pediatric patients on vigabatrin monotherapy.

Unlabelled: Vigabatrin (GVG) is an effective antiepileptic drug used for treating partial seizures in adults and children. Over the last years, an increasing number of articles have been published reporting visual field defects (VFD) associated with GVG therapy in adults. To date, however, only an small number of pediatric patients have been reported.

Patching and tearing single-wall carbon-nanotube ropes into multiwall carbon nanotubes.

Bundles of single-wall carbon nanotubes (SWCNTs) coalesce forming multiwall carbon nanotubes (MWCNTs), containing from two to six nested tubes, under thermal treatment at high temperatures [(2200-2400) degrees C]. This structural transformation is confirmed by extensive molecular dynamics (MD) simulations. The simulations suggest a "patching-and-tearing" mechanism for the single-wall-to-multiwall transformation underlying the "concerted" coalescence of the tubes that begins with their polymerization.