Publications by authors named "Maria J Gomez-Villalobos"
Recent epidemiological data suggest that diabetes is a risk factor for pulmonary arterial hypertension. The aim of the present study was to analyze the link between type 1 diabetes and pulmonary arterial dysfunction in rats. Male Sprague-Dawley rats were randomly divided into a control group (saline) and a diabetic group (70 mg/kg streptozotocin).
View Article and Find Full Text PDFDiabetes induces pulmonary artery endothelial dysfunction by NADPH oxidase induction.
Jose G Lopez-Lopez Javier Moral-Sanz Giovanna Frazziano Maria J Gomez-Villalobos Jorge Flores-Hernandez
Am J Physiol Lung Cell Mol Physiol
November 2008
Article Synopsis
- Recent research indicates that diabetes can lead to pulmonary hypertension by causing problems in the blood vessels of the lungs.
- In a study using diabetic rats, researchers found that these animals had a reduced ability for their pulmonary arteries to relax when exposed to acetylcholine, suggesting endothelial dysfunction.
- The dysfunction was linked to increased production of superoxide due to NADPH oxidase activity, and this effect could be reversed with specific inhibitors, highlighting potential therapeutic targets for managing diabetes-related vascular issues.