The human olfactory system in two proteinopathies: Alzheimer's and Parkinson's diseases.

Alzheimer's and Parkinson's diseases are the most prevalent neurodegenerative disorders. Their etiologies are idiopathic, and treatments are symptomatic and orientated towards cognitive or motor deficits. Neuropathologically, both are proteinopathies with pathological aggregates (plaques of amyloid-β peptide and neurofibrillary tangles of tau protein in Alzheimer's disease, and Lewy bodies mostly composed of α-synuclein in Parkinson's disease).

Cranial Pair 0: The Nervus Terminalis.

Originally discovered in elasmobranchs by Fritsh in 1878, the nervus terminalis has been found in virtually all species, including humans. After more than one-century debate on its nomenclature, it is nowadays recognized as cranial pair zero. The nerve mostly originates in the olfactory placode, although neural crest contribution has been also proposed.

[Rationale of Doppler urodynamics and urodynamics. What does Doppler contribute to urodynamics?].

Objectives: To make an analysis of the usefulness of urodynamic tests and what can be obtained from them.

Methods: We also perform and analytical deduction of those parameters that define detrusor behavior, such as the constant defining bladder compliance, the bladder elastic constant, in its tensile properties, and we found the expression of resistances and calculate the abdominal pressure formula; therefore we don't need to introduce a rectal catheter to know the value of those parameters that define bladder dynamics.

Results: Although they are provisional, they allow foreseeing a promising future for this application of a well-known device.