A biomarkers study of human skin fibroblasts exposition to glyphosate-based herbicide using an untargeted and targeted metabolomics approach.

Metabolomics is a valuable tool to assess glyphosate exposure and its potential impact on human health. However, few studies have used metabolomics to evaluate human exposure to glyphosate or glyphosate-based herbicides (GBHs). In this study, an untargeted and targeted metabolomics approach was applied to human skin fibroblasts exposed to the GBH Roundup (GLYP-R).

Decoding how receptor tyrosine kinases (RTKs) mediate nuclear calcium signaling.

Calcium (Ca) is a highly versatile intracellular messenger that regulates several cellular processes. Although it is unclear how a single-second messenger coordinates various effects within a cell, there is growing evidence that spatial patterns of Ca signals play an essential role in determining their specificity. Ca signaling patterns can differ in various cell regions, and Ca signals in the nuclear and cytoplasmic compartments have been observed to occur independently.