Publications by authors named "Maria Isabel Vera"
Introduction: Risk factors for developing pancreatitis due to thiopurines in patients with inflammatory bowel disease (IBD) are not clearly identified. Our aim was to evaluate the predictive pharmacogenetic risk of pancreatitis in IBD patients treated with thiopurines.
Methods: We conducted an observational pharmacogenetic study of acute pancreatitis events in a cohort study of IBD patients treated with thiopurines from the prospectively maintained ENEIDA registry biobank of GETECCU.
Article Synopsis
- Colorectal cancer (CRC) can develop in patients with long-standing ulcerative colitis (UC), and microRNAs may serve as important biomarkers for tracking this progression.
- The study examined 96 microRNAs in tissue samples from UC patients and controls, identifying 64 that were deregulated, particularly focusing on three miRNAs—miR-31, -106a, and -135b—that showed significant changes between different stages of the disease.
- Findings suggest that UC-associated CRCs have unique microRNA expression patterns compared to sporadic CRCs, with some microRNAs potentially indicating early cancer development.
Background & Aims: There is conflicting evidence regarding the prevalence of and risk factors for metabolic-associated fatty liver disease (MAFLD) in patients with inflammatory bowel disease (IBD). We aimed to determine MAFLD prevalence and risk factors in IBD patients.
Methods: Cross-sectional, case-control study included all consecutive IBD patients treated at 2 different university hospitals.
Background And Aims: Crohn's disease [CD] can develop penetrating complications at any time during the disease course. Enterocutaneous fistulae [ECF] are disease-related complications with an important impact on quality of life. Our aim was to describe the outcomes of this complication, including its medical and/or surgical management and their temporal trends.
View Article and Find Full Text PDFIntroduction: COVID-19 has altered the usual practice of medicine and the state of emergency declared in Spain on March 14th has considerably changed the activity of inflammatory bowel disease (IBD) units. The aim of this study was to evaluate the consequences of COVID-19 on the IBD Unit's activity and provide information on restructuring with available resources.
Methods: an observational study was performed in a referral hospital in Madrid (Spain).
Background: The effectiveness of the switch to another anti-tumor necrosis factor (anti-TNF) agent is not known. The aim of this study was to analyze the effectiveness and safety of treatment with a second and third anti-TNF drug after intolerance to or failure of a previous anti-TNF agent in inflammatory bowel disease (IBD) patients.
Methods: We included patients diagnosed with IBD from the ENEIDA registry who received another anti-TNF after intolerance to or failure of a prior anti-TNF agent.
Objective: Outside clinical trials, the effectiveness of chromoendoscopy (CE) for long-standing IBD surveillance is controversial. We aimed to assess the effectiveness of CE for neoplasia detection and characterisation, in real-life.
Design: From June 2012 to 2014, patients with IBD were prospectively included in a multicentre cohort study.
Introduction: Early stages of Crohn's disease [CD] are predominantly inflammatory and early treatment could be useful to change the natural history of CD. We aimed to evaluate the impact of early treatment in our cohort of CD patients.
Methods: We retrospectively reviewed clinical records of all CD patients at our centre who have received immunomodulators.
Background And Aims: nursing management of inflammatory bowel disease (IBD) is highly relevant for patient care and outcomes. However, there is evidence of substantial variability in clinical practices. The objectives of this study were to develop standards of healthcare quality for nursing management of IBD and elaborate the evaluation tool "Nursing Care Quality in IBD Assessment" (NCQ-IBD) based on these standards.
View Article and Find Full Text PDFObjective: To evaluate effectiveness and safety of adalimumab in CD patients of the Madrid area and identify predictors of response.
Methods: Multicenter retrospective survey of all CD patients treated with adalimumab in 9 hospitals of the Madrid area (Spain). Univariate and multivariate analysis of predictors of response was performed.
Background: Nurses play an important role in the multidisciplinary management of inflammatory bowel disease (IBD), but little is known about this role and the associated resources.
Objective: To improve knowledge of resource availability for health care activities and the different organizational models in managing IBD in Spain.
Methods: Cross-sectional study with data obtained by questionnaire directed at Spanish Gastroenterology Services (GS).
Background: The purpose of quality of care programs is to improve patient outcomes. In programs targeting patients with inflammatory bowel disease (IBD), nurses play a key role.
Aim: To know the available scientific evidence on the quality of care in IBD management, at the levels of structure, process and outcome, in relation to nurses.
Immunosuppressive or biological treatment in patients with inflammatory bowel disease can modify the natural history of their disease, although these treatments are not universally effective and can have severe adverse effects. Attempts have been made to identify predictive factors of response to the various therapeutic options in order to aid the choice of the most appropriate therapeutic alternative in each patient. The possibility of modifying any one of these predictive factors would be of great interest since it would provide the opportunity to alter the course of the disease.
View Article and Find Full Text PDFAims: To evaluate efficacy and safety of oral tacrolimus in cases of fistulizing Crohn's disease (FCD), which is refractory to conventional therapy including infliximab.
Methods: Patients with fistulas, previously and unsuccessfully treated with all conventional therapy (i.e.