Group 2 vaccinia virus, Brazil.

In 2011, vaccinia virus caused an outbreak of bovine vaccinia, affecting dairy cattle and dairy workers in Brazil. Genetic and phenotypic analyses identified this isolate as distinct from others recently identified, thereby reinforcing the hypothesis that different vaccinia virus strains co-circulate in Brazil.

Filling one more gap: experimental evidence of horizontal transmission of Vaccinia virus between bovines and rodents.

Vaccinia virus (VACV) has been associated with several exanthematic outbreaks in bovine, human, and equine species in Brazilian rural areas. Little is known about VACV reservoirs, although it is believed that rodents could be associated with VACV outbreaks. With the goal of filling one more gap in the VACV ecological puzzle, the present work aimed at mimicking a potential transmission route of VACV between cows and rodents, both known as natural VACV hosts.