Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts.

We have investigated gene expression profiles of human ovarian carcinomas in vivo during Taxol(R) (paclitaxel) treatment and observed a difference in expression. Nude mice bearing 1A9 or 1A9PTX22 xenografts were given 60 mg/kg of paclitaxel. Therapeutic efficacy was achieved for 1A9, while 1A9PTX22 did not respond.

The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically.

Purpose: The purpose of this study was to investigate the antitumor activity of SU6668, tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor beta (PDGFRbeta), as single-agent therapy and in combination with paclitaxel on ovarian carcinoma xenograft models transplanted in the peritoneal cavity of nude mice.

Experimental Design: HOC22 and HOC79 ascites-producing human ovarian carcinoma xenografts were transplanted i.p.

Small molecules in anti-angiogenic therapy.

Angiogenesis, or the formation of new blood vessels from preexisting capillaries, is a sequence of events that occurs in many physiological and pathological conditions, including cancer. The identification of several pro-angiogenic factors and the recent description of endogenous inhibitors of angiogenesis, has made interference with vessel formation an attractive potential therapeutic option. Several compounds with anti-angiogenic or antivascular properties have been identified, and several of them have entered patient studies in cancer on the basis of promising preclinical results.

Antiangiogenic and antitumor activity of IDN 5390, a new taxane derivative.

Purpose: We previously reported that paclitaxel, a microtubule-stabilizing drug, inhibited angiogenesis, mainly by inhibiting endothelial cell motility (D. Belotti et al., Clin.