Publications by authors named "Maria Ines De Armas"
Article Synopsis
- * The study focuses on the peroxiredoxin AhpE, showing that its sulfenic acid form (AhpE-SOH) reacts quickly with HS to produce a detectable persulfide (AhpE-SSH), which has a significantly higher reaction rate than with conventional thiols.
- * Molecular dynamics simulations suggest that the reactivity changes in AhpE after forming AhpE-SSH may be linked to structural alterations in the active site, indicating that peroxiredoxins like
Mitochondria are main sites of peroxynitrite formation. While at low concentrations mitochondrial peroxynitrite has been associated with redox signaling actions, increased levels can disrupt mitochondrial homeostasis and lead to pathology. Peroxiredoxin 3 is exclusively located in mitochondria, where it has been previously shown to play a major role in hydrogen peroxide reduction.
View Article and Find Full Text PDFSignificance: Mycothiol (MSH, AcCys-GlcN-Ins) is the main low-molecular weight (LMW) thiol of most Actinomycetes, including the human pathogen Mycobacterium tuberculosis that affects millions of people worldwide. Strains with decreased MSH content show increased susceptibilities to hydroperoxides and electrophilic compounds. In M.
View Article and Find Full Text PDFMycobacterium tuberculosis (M. tuberculosis) is the intracellular bacterium responsible for tuberculosis disease (TD). Inside the phagosomes of activated macrophages, M.
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