Clinical Experience on the Use of a Single-day, Two-injection Start Initiation Regimen of Aripiprazole Once Monthly in Patients With Schizophrenia in Spain: SaTISfy Study.

Objective: The two-injection start (TIS) initiation regimen was recently approved for aripiprazole once monthly 400 mg (AOM400), with potential benefits in adherence. The SaTISfy study described in this article analyzed Spanish psychiatrists' perspectives on hospitalization lengths of stay, schizophrenia management, and the use of AOM400-TIS.

Methods: The authors describe an ecological study of aggregated data collected using a 41-question survey.

Office-Based Procedures in the Management of Hemorrhoidal Disease: Rubber Band Ligation versus Sclerotherapy - Systematic Review and Meta-Analysis.

Introduction: The most frequently used office-based procedures in hemorrhoidal disease (HD) are rubber band ligation (RBL) and sclerotherapy. Few studies have been published comparing the various types of instrumental therapy. The aim of this systematic review and meta-analysis was to compare the efficacy and safety of sclerotherapy and RBL.

cDC1 are required for the initiation of collagen-induced arthritis.

Rheumatoid arthritis (RA) is chronic autoimmune disease which etiology remains unknown. Several cell types have been described to potentiate/aggravate the arthritic process however the initiating event in synovial inflammation is still elusive. Dendritic cells (DCs) are essential for the initiation of primary immune responses and thus we hypothesized that these cells might be crucial for RA induction.

Missense Gamma-Aminobutyric Acid Receptor Polymorphisms Are Associated with Reaction Time, Motor Time, and Ethanol Effects .

The Gamma-aminobutyric acid type A receptor (GABA-A receptor) is affected by ethanol concentrations equivalent to those reached during social drinking. At these concentrations, ethanol usually causes impairment in reaction and motor times in most, but not all, individuals. To study the effect of GABA-A receptor variability in motor and reaction times, and the effect of low ethanol doses.

Intraspecies geographical variability in the South American tigra mariposa (Bothrops venezuelensis Sandner 1952) snake venom activities.

Bothrops venezuelensis snake venoms, from five localities in the North-Central Venezuelan regions, showed biochemical and haemostatic differences. In this study, bioactivities of B. venezuelensis venoms from different regions (Aragua state; Waraira Repano (Capital District); Baruta, La Boyera and Lagunetica (Miranda state)) were compared using both natural and synthetic substrates.

A minute ostracod (Crustacea: Cytheromatidae) from the Miocene Solimões Formation (western Amazonia, Brazil): evidence for marine incursions?

A huge wetland (the 'Pebas system') covered western Amazonia during the Miocene, hosting a highly diverse and endemic aquatic fauna. One of the most contentious issues concerns the existence, potential pathways and effects of marine incursions on this ecosystem. Palaeontological evidences (body fossils) are rare.

Taxonomy and bathymetric distribution of the outer neritic/upper bathyal ostracodes (Crustacea: Ostracoda) from the southernmost Brazilian continental margin.

Sixty-five ostracode species belonging to 41 genera and 17 families were recorded in the outer shelf and upper slope off Rio Grande do Sul and Santa Catarina states, southernmost Brazil, between 100 and 586 m water depth interval. The ostracode occurrences are hypothesized to be influenced by both, the coastal waters and the Antarctic Intermediate Water (AAIW). The taxonomy of some species of Bradleya Hornibrook, 1952, Legitimocythere Coles & Whatley, 1989 and Henryhowella Puri, 1957 previously described in the same study area is revised.

Reduced CLEC9A expression in synovial tissue of psoriatic arthritis patients after adalimumab therapy.

Objectives: We aimed to investigate the early changes in expression of C-type lectin domain family 9, member A (CLEC9A), a C-type lectin that is specifically expressed by the CD141(+) dendritic cell subset that is involved in cross-presentation to CD8(+) T cells, by evaluating gene and/or protein expression in three different compartments [skin, synovial tissue (ST) and serum] after short-term adalimumab treatment in PsA patients compared with placebo.

Methods: Patients with active PsA and psoriasis were randomized to receive adalimumab or placebo for 4 weeks. Synovial and skin biopsies were obtained before and after 4 weeks of treatment and serum samples 4 weeks, 12 weeks and 1 year after treatment.

On the Miocene Cyprideis species flock (Ostracoda; Crustacea) of Western Amazonia (Solimões Formation): Refining taxonomy on species level.

The Miocene mega-wetland of western Amazonia holds a diverse, largely endemic ostracod fauna. Among them, especially the genus Cyprideis experienced a remarkable radiation. Micropalaeontologic investigations of a 400 m long sediment core (~62 km SW Benjamin Constant, Amazonia, Brazil) permitted a taxonomic revision of about two-thirds of hitherto described Cyprideis species.

[Importance of health CRM in pandemics and health alerts].

Objective: The aim of this article is to demonstrate the importance of the role a health CRM can play in a pandemic or health alert. During the influenza-A pandemic, Salud Responde played a very important role. Its main objective was to establish protocols and citizens advice lines that would avoid patients with mild influenza-A symptoms going to health centre.

FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis in rheumatoid arthritis.

Introduction: The FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis plays a fundamental role in proliferation and differentiation of dendritic cells (DCs). As DCs play an important role in rheumatoid arthritis (RA) immunopathology we studied in detail the Flt3L/CD135 axis in RA patients.

Methods: The levels of Flt3L in (paired) serum and synovial fluid (SF) were quantified by enzyme-link immunosorbent assay (ELISA).

Ostracods (Crustacea) and their palaeoenvironmental implication for the Solimões Formation (Late Miocene; Western Amazonia/Brazil).

Western Amazonia's landscape and biota were shaped by an enormous wetland during the Miocene epoch. Among the most discussed topics of this ecosystem range the question on the transitory influx of marine waters. Inter alia the occurrence of typically brackish water associated ostracods is repeatedly consulted to infer elevated salinities or even marine ingressions.

Actinomycosis affecting the spinal cord: a case report.

Actinomycosis is a rare, chronic, suppurative, granulomatous infection caused by a group of gram-positive anaerobic bacteria belonging to the natural flora of the oral cavity and gastrointestinal and urogenital tracts. It may involve several organs. This case study refers to pulmonary actinomycosis with chest wall involvement and cord compression in a 29-year-old male who presented with fever, cough, hemoptysis, neck pain, and paresis and plegia of the lower limbs of 5-month duration.

[Toscana virus in the Portuguese population: serosurvey and clinical cases].

Toscana virus (Phlebovirus genus, Bunyaviridae family) is a neurotropic virus which circulates in the Mediterranean Basin. Although Portugal has been the second country where its presence was reported, the existence of this virus in our country has been referred only sporadically, and there is a lack of knowledge regarding the prevalence of antibodies in the population. Thus, the objective of this study was to analyse the prevalence of antibodies anti-Toscana virus in the human population in our country.

Late Miocene sedimentary environments in south-western Amazonia (Solimões Formation; Brazil).

In Miocene times a vast wetland existed in Western Amazonia. Whereas the general development of this amazing ecosystem is well established, many questions remain open on sedimentary environments, stratigraphical correlations as well as its palaeogeographical configuration. Several outcrops located in a barely studied region around Eirunepé (SW Amazonas state, Brazil) were investigated to obtain basic sedimentological data.

Variability in ethanol biodisposition in whites is modulated by polymorphisms in the ADH1B and ADH1C genes.

Unlabelled: Association between genetic variations in alcohol-related enzymes and impaired ethanol biodisposition has not been unambiguously proven, and the effect of many newly described polymorphisms remains to be explored. The aims of this study are to elucidate the influence of genetic factors in alcohol biodisposition and effects. We analyzed alcohol pharmacokinetics and biodisposition after the administration of 0.

Levelling profiles and a GPS network to monitor the active folding and faulting deformation in the Campo de Dalias (Betic Cordillera, southeastern Spain).

The Campo de Dalias is an area with relevant seismicity associated to the active tectonic deformations of the southern boundary of the Betic Cordillera. A non-permanent GPS network was installed to monitor, for the first time, the fault- and fold-related activity. In addition, two high precision levelling profiles were measured twice over a one-year period across the Balanegra Fault, one of the most active faults recognized in the area.

Cutaneous disorders in the "bairro Inhamudima" of Beira, Mozambique.

Background: There are no reliable data on the prevalence of skin diseases in Mozambique.

Aim: To address this issue and to apply the findings to the dermatology teaching program at the Universidade Católica de Moçambique.

Methods: Medical students attempted to identify the most common skin disorders in the "bairro Inhamudima" of Beira, Mozambique by conducting a population survey.

Bocaiuva (Acrocomia aculeata (Jacq.) Lodd) improved Vitamin A status in rats.

Carotenoid bioavailability is influenced by various factors including the food matrix. The release of those molecules from the food matrix is the initial and most important step in the absorption process. The relative bioavailability of bocaiuva pulp beta-carotene in relation to pure beta-carotene was assayed by a hepatic retinol store, in vitamin A deficient Wistar rats.