Publications by authors named "Maria I Markelova"
Article Synopsis
- Inflammatory bowel diseases involve ongoing inflammation in the intestines and changes in gut microbiota, which can be influenced by outer membrane vesicles (OMVs) that contain polysaccharide A (PSA).
- The study used a mouse model of intestinal colitis induced by sodium dextran sulfate (DSS) and examined the effects of OMV treatment by assessing disease severity and gut tissue health through disease activity index (DAI) and histology.
- Results indicated that OMV treatment improved intestinal healing and altered microbiota composition, highlighting OMVs’ potential as both anti-inflammatory agents and facilitators of microbiota recovery.
Article Synopsis
- Actinobacteria, particularly the Nocardia genus, thrive in diverse environments and have significant agricultural and industrial importance.
- Screening extreme habitats for Nocardia can yield beneficial strains for biotechnological applications.
- The novel strain Nocardia mangyaensis NH1 produces various bioactive compounds, including siderophores, which can enhance soil fertility and support plant growth through metal-chelating and antifungal properties without harming plant seedlings.
The biosafety of gene therapy remains a crucial issue for both the direct and cell-mediated delivery of recombinant cDNA encoding biologically active molecules for the pathogenetic correction of congenital or acquired disorders. The diversity of vector systems and cell carriers for the delivery of therapeutic genes revealed the difficulty of developing and implementing a safe and effective drug containing artificial genetic material for the treatment of human diseases in practical medicine. Therefore, in this study we assessed changes in the transcriptome and secretome of umbilical cord blood mononuclear cells (UCB-MCs) genetically modified using adenoviral vector (Ad5) carrying cDNA encoding human vascular endothelial growth factor (VEGF165) or reporter green fluorescent protein (GFP).
View Article and Find Full Text PDFGenomic and metabolomic studies of endolithic bacteria are essential for understanding their adaptations to extreme conditions of the rock environment and their contributions to mineralization and weathering processes. The endoliths of arid serpentine rocks are exposed to different environmental stresses, including desiccation and re-hydration, temperature fluctuations, oligotrophy, and high concentrations of heavy metals. Bacteria of the genus Rhodococcus commonly inhabit endolithic environments.
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- * Researchers sequenced genomes from 63 gut strains of CD patients and healthy individuals, revealing similar genetic traits related to virulence and antibiotic resistance.
- * Findings indicate competitive bacteria interactions in the gut that could potentially harm the host, highlighting the complex dynamics of gut microbiota in CD.
Introduction: Dysregulation of NLRP3 inflammasome complex formation can promote chronic inflammation by increased release of IL-1β. However, the effect of NLRP3 complex formation on tumor progression remains controversial. Therefore, we sought to determine the effect of NLRP3 modulation on the growth of the different types of cancer cells, derived from lung, breast, and prostate cancers as well as neuroblastoma and glioblastoma .
View Article and Find Full Text PDFThe success of members of the genus Rhodococcus in colonizing arid rocky environments is owed in part to desiccation tolerance and an ability to extract iron through the secretion and uptake of siderophores. Here, we report a comprehensive genomic and taxonomic analysis of Rhodococcus qingshengii strain S10 isolated from eathered serpentine rock at the arid Khalilovsky massif, Russia. Sequence comparisons of whole genomes and of selected marker genes clearly showed strain S10 to belong to the R.
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- This study explores the gut microbiota and IBD biomarkers in patients from Kazan, Russia, addressing the growing interest in IBD in newly industrialized countries.* -
- Researchers found significant changes in the gut microbiota of IBD patients, including increased levels of certain bacteria and decreased levels of beneficial species, indicating a dysbiotic state.* -
- The findings suggest that these changes, particularly the imbalance of short-chain fatty acids (SCFAs), may impact important metabolic processes like hydrogen metabolism, which is crucial for understanding the disease.*
Article Synopsis
- * Tests on colon samples from CC patients showed that spontaneous motility remained unchanged, but responses to certain contractions were heightened, indicating preserved muscle contractility and increased sensitivity to nerve stimulation.
- * The composition of gut microbiota in CC patients showed typical human characteristics with some low levels of beneficial bacteria, but no specific microbial markers for constipation were identified, suggesting a functional role of the overall microbiota instead.
Endolithic microbial communities survive nutrient and energy deficient conditions while contributing to the weathering of their mineral substrate. This study examined the mineral composition and microbial communities of fully serpentinized weathered rock from 0.1 to 6.
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- * A study showed that HP eradication therapy significantly reduced gut microbiota diversity and altered the abundance of various microbial species.
- * Changes in antibiotic resistance genes (ARGs) were observed post-therapy, with some strains exhibiting higher resistance to specific antibiotics like macrolides and tetracyclines compared to others.
Article Synopsis
- - The study presents the genome sequence of strain PS2, which was isolated from hydrocarbon sludge at an organic synthesis factory.
- - This strain can use a variety of -alkanes (specifically from C to C) as its only source of carbon.
- - Understanding the genome will help reveal how this strain breaks down long-chain -alkanes, which is important for biodegradation processes.
Article Synopsis
- The study focused on analyzing the changes in skin bacteria of wrestlers during training and how these bacteria respond to different antiseptics.
- Researchers identified key bacterial strains from the skin of 15 wrestlers using specific lab techniques and tested the effectiveness of several antiseptics against these bacteria.
- The findings revealed an increase in harmful bacteria on wrestlers' skin, indicating a decrease in skin protection, while Veltosept-2 was found to be the most effective antiseptic in preventing infections.
Article Synopsis
- The report presents shotgun sequencing data related to a study on gut microbiome changes during and after antibiotic eradication therapy for infections.
- It includes whole-genome sequencing of DNA from stool samples taken before, during, and after treatment to analyze the gut microbiota's taxonomic and functional profiles.
- The data highlights significant alterations in intestinal microbiota composition due to antibiotic use and is part of a larger metagenomic analysis, with associated sequencing available under project ID PRJEB21338 in the ENA database.