Elm1 kinase activates the spindle position checkpoint kinase Kin4.

Budding yeast asymmetric cell division relies upon the precise coordination of spindle orientation and cell cycle progression. The spindle position checkpoint (SPOC) is a surveillance mechanism that prevents cells with misoriented spindles from exiting mitosis. The cortical kinase Kin4 acts near the top of this network.

Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation.

Rationale: Recovering the neutrophil migration to the infectious focus improves survival in severe sepsis. Recently, we demonstrated that the cystathionine gamma-lyase (CSE)/hydrogen sulfide (H(2)S) pathway increased neutrophil recruitment to inflammatory focus during sterile inflammation.

Objectives: To evaluate if H(2)S administration increases neutrophil migration to infectious focus and survival of mice.