Publications by authors named "Maria I Barriga"
Article Synopsis
- A study compared high-risk HPV (hrHPV) testing and cytology for cervical cancer screening, finding hrHPV testing had higher sensitivity but a lower positive predictive value than cytology.
- About 10.7% of over 8,000 women tested positive for hrHPV, with HPV16/18 genotyping identifying higher prevalence of CIN2+ lesions among positive cases.
- Using HPV16/18 genotyping reduces unnecessary referrals and colposcopies, allowing for better risk stratification, where positive cases warrant immediate referral while negative cases can be monitored more closely.
Article Synopsis
- Thrombocytosis is linked to a worse prognosis in ovarian cancer patients, with platelets influencing tumor progression and metastasis.
- Co-culturing ovarian cancer cells with platelets led to changes in cell phenotype, increased migration, and higher levels of metastatic markers and Tissue Factor (TF).
- The study suggests that interactions between platelets and cancer cells contribute to the formation of metastatic tumors in ovarian cancer.
Article Synopsis
- A population-based trial in Santiago, Chile compared the effectiveness of HPV DNA testing with the traditional Papanicolaou (Pap) test for cervical cancer screening in women aged 25 to 64.
- Out of 8,265 women screened, 11.3% tested positive for cervical issues, with an observed prevalence of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) at 1.1%, and nine cases of invasive cervical cancer.
- HPV testing demonstrated significantly higher sensitivity (92.7%) for detecting CIN2+ compared to Pap testing (22.1%), indicating that the molecular test is not only feasible but may enhance cervical cancer screening programs in Chile.
Article Synopsis
- Cervical cancer mortality rates in Chile are higher than in developed countries, exacerbated by socioeconomic disparities.
- The recognition of HPV as the primary cause has shifted prevention strategies towards vaccination and HPV detection in women over 30.
- The article suggests replacing the less effective Pap test with HPV detection in the existing prevention program, along with training personnel for better triage processes, aiming to reduce deaths and inequalities in cervical cancer outcomes.
The use of the type 2 diabetics drug metformin has been correlated with enhanced progression-free survival in ovarian cancer. The literature has speculated that this enhancement is due to the high concentration of metformin directly causing cancer cell death. However, this explanation does not fit with clinical data reporting that the women exposed to constant micromolar concentrations of metformin, as present in the treatment of diabetes, respond better to chemotherapy.
View Article and Find Full Text PDFObjective: To evaluate acceptance, preference and compliance with referral of vaginal self-sampling for the detection of Human papillomavirus (HPV) among women non-adherent to Papanicolaou (Pap) screening in Santiago, Chile.
Materials And Methods: Using multistage sampling we identified women aged 30-64 years who reported not receiving a Pap test in the previous three years and offered them Pap testing at the health center or vaginal self-sampling for HPV testing at home. Self-collected samples were analyzed with hybrid capture.
Article Synopsis
- Cervical cancer mortality rates in Chile are significantly higher than in developed countries, prompting a study comparing the effectiveness of HPV DNA testing versus conventional Pap testing in detecting cervical lesions.
- The study involved over 8,200 women in Santiago, revealing that HPV testing was substantially more sensitive (92.7%) for identifying precancerous and cancerous lesions (CIN2+) compared to Pap testing (22.1%).
- The findings suggest that HPV testing is a more effective method for cervical cancer screening in a developing country context, leading to better identification of at-risk women and enhancing existing cervical cancer prevention programs.
Objective: To analyze 6 different types of visible anterior occlusion, exclusive of extraoral facial features, in terms of their esthetic appeal, as perceived by 91 randomly selected adult laypersons with different levels of education in Lima, Peru.
Methods: Photographic images of 3 examples of each occlusion type (open bite [OB], deep bite [DB], crossbite [CB], end-to-end bite [EE], crowded bite [CwB] and ideal bite [IB]) were prepared. Evaluators used a visual analogue scale (VAS) to rate their perceptions of the esthetic appeal of each view.
Short neck and fusion of cervical vertebrae are observed in several genetic conditions and well-defined syndromes. An 8-year-old boy with a short neck, low-set posterior hairline, deafness and limited neck motion was suspected of having such a condition. Clinical and radiographic examination led to the diagnosis of Klippel-Feil syndrome.
View Article and Find Full Text PDF