The Effect of Plantago major on Wound Healing in Preclinical Studies: A Systematic Review.

Background: Plantago major is a medicinal plant that has been used for centuries to treat various health conditions including wounds.

Purpose: To investigate the effectiveness of the topical use of P major in healing skin wounds in animal models.

Methods: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic review was conducted.

A randomized controlled trial on the effect of behavioral strategies for adherence to oral antidiabetic drugs: study protocol.

Background: Non-adherence to oral antidiabetics drugs (OADs) has been a common problem and may contribute to poor glycemic control.

Aim: To describe an experimental study protocol that aims at implementing and evaluating the effect of the "action planning and coping planning" interventions on medication adherence to OADs in patients with type 2 diabetes mellitus (T2DM) in follow-up at primary care services.

Design: A randomized controlled trial.

Evaluating the Effect of 3% Papain Gel Application in Cutaneous Wound Healing in Mice.

Unlabelled: While the US Food and Drug Administration has not approved the use of 3% papain gel in the United States, the authors feel this study adds to the literature regarding its use.

Introduction: The aim of this study was to evaluate the effect of 3% papain gel on wounds in mice.

Materials And Methods: Thirty healthy C57BL mice (25-30 g) aged 10 weeks were randomly divided into 2 groups: mice treated with 3% papain gel and mice treated with placebo gel.

Prevalence and clinical significance of potential drug-drug interaction in hematopoietic stem cell transplantation.

Patients undergoing hematopoietic stem cell transplantation (HSCT) are at risk of developing potential drug-drug interactions (PDDIs). The aim of this study was to assess the prevalence of PDDIs that occur in HSCT patients on the day of hematopoietic stem cell infusion. We performed a cross-sectional study based on the evaluation of prescriptions to HSCT patients on the day of infusion (day 0).

Regulation of IRS-1/SHP2 interaction and AKT phosphorylation in animal models of insulin resistance.

Insulin stimulates tyrosine kinase activity of its receptor, resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1, which, in turn, associates with proteins containing SH2 domains, including phosphatidylinositol 3-kinase (PI 3-kinase) and the phosphotyrosine phosphatase SHP2. The regulation of these associations in situations of altered insulin receptor substrate-1 (IRS-1) phosphorylation was not yet investigated. In the present study, we investigated insulin-induced IRS-1/SHP2 and IRS-1/PI 3-kinase associations and the regulation of a downstream serine-kinase AKT/PKB in liver and muscle of three animal models of insulin resistance: STZ diabetes, epinephrine-treated rats, and aging, which have alterations in IRS-1 tyrosine phosphorylation in common.