Publications by authors named "Maria Helena Kraemer"
Human leukocyte antigen (HLA) and single nucleotide polymorphisms (SNPs) tumor necrosis factor (TNF)-alpha -238 and -308 as genetic markers of susceptibility to psoriasis and severity of the disease in a long-term follow-up Brazilian study.
Renata Ferreira Magalhães Ana Cristina Biral João Alexandre Trés Pancoto Eduardo Antonio Donadi Celso Texeira Mendes Maria Helena Kraemer
Int J Dermatol
October 2010
Article Synopsis
- The Cw*06 genetic marker is strongly associated with psoriasis, with specific TNF-alpha polymorphisms linked to disease severity in Brazilian patients.
- A study involving 69 psoriasis patients and 70 controls found that male patients typically exhibited more severe disease.
- While TNF SNPs -238 and -308 showed no significant differences between patients and controls, the TNF-238 G/G genotype was linked to a higher risk of severe disease, suggesting it may influence clinical outcomes rather than overall genetic susceptibility.