Association of the T130I Variant of the Gene with Metabolic Syndrome and Its Components in Mexican Children.

Metabolic syndrome (MetS), a cluster of risk factors, leads to cardiovascular disease (CVD) and type 2 diabetes (T2D). The second leading cause of mortality in Mexico is T2D. Genetic factors participate in the pathogenesis of MetS.

Genetic variability of CYP2C9*2 and CYP2C9*3 in seven indigenous groups from Mexico.

Aim: CYP2C9 is one of the major drug metabolizing enzymes, however, little is known about polymorphisms in CYP2C9 gene and pharmacological implications in Mexican indigenous populations. Thus, frequencies of CYP2C9*2 and CYP2C9*3 alleles were evaluated in indigenous groups located in northwest (Cora), center (Mazahua and Teenek), south (Chatino and Mixteco) and southeast (Chontal and Maya) regions Mexico.

Materials & Methods: Allelic discrimination was performed by real-time PCR.