Publications by authors named "Maria Haque"
Breast cancer (BC) is a leading cause of cancer-related mortality among women worldwide. BC is regarded as a systemic disease. Consequently, the majority of BC patients undergo systemic therapy to reduce the risk of distant metastasis (DM) and associated mortality.
View Article and Find Full Text PDFOsteosarcoma (OSA) is the most common type of primary bone malignancy in people and dogs. Our previous molecular comparisons of canine OSA against healthy bone resulted in the identification of differentially expressed protein-expressing genes (forkhead box protein O4 (), interferon regulatory factor 8 (), and lymphoid enhancer binding factor 1 ()). Immunohistochemistry (IHC) and H-scoring provided semi-quantitative assessment of nuclear and cytoplasmic staining alongside qualitative data to contextualise staining ( = 26 patients).
View Article and Find Full Text PDFArticle Synopsis
- Breast cancer classified as HER2 Low is a new category that requires more detailed understanding regarding its clinical and molecular characteristics, particularly in relation to treatment response and patient outcomes.
- The study analyzed two distinct breast cancer cohorts, examining the profiles of HER2 Low tumors through various biological and immunological tests and confirming findings with additional advanced sequencing techniques.
- Results indicated that most HER2 Low tumors are hormone receptor positive and have a better prognosis compared to HER2 negative tumors, while hormone receptor negative HER2 Low tumors show distinct immune profiles and longer survival rates.
Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.
View Article and Find Full Text PDF