Publications by authors named "Maria H Esteva-Spinetti"

Objective: To examine the predictors of the occurrence of severe thrombocytopenia and its impact on damage accrual and mortality in SLE patients.

Methods: Factors associated with time to severe thrombocytopenia (platelet count ≤20,000/mm) occurring from the onset of SLE symptoms were assessed by Cox proportional hazards regressions. The association of severe thrombocytopenia with mortality was evaluated by logistic regression analyses while its impact on damage was by negative binomial regression.

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  • - The study investigates the characteristics and effects of the time taken to diagnose systemic lupus erythematosus (SLE) in a Latin American cohort, noting that diagnosis can often be delayed and that SLE may resemble other diseases.
  • - Patients with longer diagnosis times (over 6 months) were often older, female, of Mestizo descent, uninsured, and displayed atypical symptoms, but this delayed diagnosis did not seem to affect their disease progression or mortality rates significantly.
  • - Overall, the research concludes that within this cohort, waiting up to 24 months for an SLE diagnosis, with a median of 6 months, did not lead to worse health outcomes.
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  • This study examined the predictors and consequences of severe autoimmune hemolytic anemia (AIHA) in patients with systemic lupus erythematosus (SLE).
  • Among 1,349 SLE patients, 3.6% developed severe AIHA over an average follow-up of 5.4 years, with male sex and higher initial disease activity linked to a quicker onset.
  • Interestingly, while hematological issues showed a trend towards significance in predicting severe AIHA, the occurrence of severe AIHA did not appear to significantly influence damage or mortality in these patients.
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  • The study investigates factors influencing neuropsychiatric (NP) manifestations in patients with newly diagnosed Systemic Lupus Erythematosus (SLE), aiming to identify both disease-related and demographic factors.
  • A total of 1,193 patients without NP involvement at the start were analyzed using clinical and lab data, applying a multivariable regression model to find independent risk factors.
  • Key findings highlight that certain conditions like myalgias, pneumonitis, and hemolytic anemia increase the risk of NP involvement, while longer disease duration at the start is linked to a lower risk.
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Aim: A decrease in proteinuria has been considered protective from renal damage in lupus nephritis (LN), but a cut-off point has yet to be established. The aim of this study was to identify the predictors of renal damage in patients with LN and to determine the best cut-off point for a decrease in proteinuria.

Methods: We included patients with LN defined clinically or histologically.

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Objectives: This study aimed to compare the clinical features, damage accrual, and survival of patients with familial and sporadic systemic lupus erythematosus (SLE).

Methods: A multi-ethnic, multinational Latin American SLE cohort was studied. Familial lupus was defined as patients with a first-degree SLE relative; these relatives were interviewed in person or by telephone.

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The original version of this article, unfortunately, contained an error. The first and family name of Loreto Massardo was interchanged and is now presented correctly in this article.

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Objectives: To identify baseline predictors of remission and low disease activity (LDA) in early rheumatoid arthritis (RA) from the GLADAR (Grupo Latino Americano De estudio de la Artritis Reumatoide) cohort.

Methods: Patients with 1- and 2-year follow-up visits were included. Remission and LDA were defined by DAS28-ESR (< 2.

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Objective: To determine the predictors of remission and low disease activity state (LDAS) in patients with systemic lupus erythematosus (SLE).

Methods: Three disease activity states were defined: Remission = SLE Disease Activity Index (SLEDAI) = 0 and prednisone ≤ 5 mg/day and/or immunosuppressants (maintenance dose); LDAS = SLEDAI ≤ 4, prednisone ≤ 7.5 mg/day and/or immunosuppressants (maintenance dose); and non-optimally controlled state = SLEDAI > 4 and/or prednisone > 7.

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Objective: To examine hematological manifestations' correlates and their impact on damage accrual and mortality in SLE patients from the multiethnic, Latin American, GLADEL cohort.

Methods: In patients with recent SLE diagnosis (≤2 years), the association between follow-up hematological manifestations (per ACR criteria) and socio-demographic and clinical variables was examined by univariable and multivariable logistic regressions; their impact on damage accrual and mortality was examined by Poisson and Cox proportional-hazards regression analyses, respectively.

Results: Of 1437 patients, 948 (66.

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Purpose: To determine the association between the number of flares systemic lupus erythematosus (SLE) patients experience and damage accrual, independently of other known risk factors.

Methods: SLE patients (34 centres, nine Latin American countries) with a recent diagnosis (≤2 years) and ≥3 evaluations were studied. Disease activity was ascertained with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and damage with the SLICC/ACR Damage Index (SDI).

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  • The study aimed to assess how socioeconomic factors influence disease activity in early rheumatoid arthritis patients from Latin America.
  • The research involved evaluating clinical data from 1,093 patients, analyzing variables such as age, sex, education, and medical coverage impact on disease severity and disability.
  • Key findings revealed that low socioeconomic status, female gender, and lack of medical coverage were linked to poorer health outcomes, with significant variations in disease activity observed across different countries and ethnic groups.
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Objective: To examine the role of ethnicity and the use of anti-malarials (protective) on lupus renal disease.

Methods: A nested case-control study (1:2 proportion, n = 265 and 530) within GLADEL's (Grupo Latino Americano De Estudio de Lupus) longitudinal inception cohort was carried out. The end-point was ACR renal criterion development after diagnosis.

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To evaluate disease characteristics of childhood onset SLE in Latin America and to compare this information with an adult population in the same cohort of GLADEL. A protocol was designed as a multicenter, multinational, inception cohort of lupus patients to evaluate demographic, clinical, laboratory and serological variables, as well as classification criteria, disease activity, organ damage and mortality. Descriptive statistics, chi square, Fisher's exact test, Student's t test and multiple logistic regression were used to compare childhood and adult onset SLE.

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