Publications by authors named "Maria Giuseppina Strillacci"
Article Synopsis
- A study aimed to identify specific genes and pathways related to the early formation of fibro-atheromas in a swine model of atherosclerosis, given the complexity of the condition's biological pathways.
- The research used a model of Familial Hypercholesterolemia and controlled pigs, analyzing tissue samples from the infrarenal aorta after 12 months to find differential gene expression.
- The key findings highlighted ITGB2 as a significant hub gene associated with inflammation and early disease progression, suggesting its potential as a therapeutic target.
Article Synopsis
- - The review explores various pig breeds that have distinct belted coat patterns, highlighting their unique phenotypic traits and geographic diversity globally.
- - Research has been conducted using the FAO domestic animal diversity information system to identify breeds with black or red piebald coat patterns across different countries.
- - Advancements in genomic technologies allow for the identification of genes linked to the belted phenotype, enhancing our understanding of these breeds' origins, histories, and genetic diversity, which is vital for preserving animal biodiversity.
Article Synopsis
- The study examined the variability in physical characteristics of two Italian turkey breeds: Brianzolo (BRZ) and Nero d'Italia (NIT) through various measurements and indexes.
- A total of 92 turkeys were analyzed, revealing that NIT was heavier and had longer body lengths compared to BRZ, along with observable sexual dimorphism where males were generally larger than females.
- The research highlights significant differences in various morphometric and colorimetric traits, aiming to aid in the preservation and genetic improvement of these heritage breeds at risk of extinction.
Article Synopsis
- Italian autochthonous turkey breeds are crucial for genetic biodiversity, and the study aimed to explore their genomic diversity using methods like run of homozygosity (ROH) and principal component analysis.
- The research focused on seven specific heritage turkey breeds, identifying unique ROH_islands that contain significant genes related to reproduction efficiency.
- Findings indicated that while most breeds are distinct, the Roma breed is a mixture of several populations, highlighting previously unknown genetic variation in these turkey breeds.
Article Synopsis
- Blood samples from 260 cattle were analyzed to study the association between specific genetic markers and the risk of bladder tumors caused by papillomavirus infections.
- The DRB322 allele was found in healthy cattle, indicating it may provide protection against urinary bladder virus infections, which are linked to tumor development.
- Two variants of another allele, DRB3011, were identified; the DRB3011:01 allele showed protective amino acids that may lower infection risk, while the DRB3011:02v allele featured susceptibility amino acids associated with a higher risk of tumors.
Article Synopsis
- The study presents a high-quality genome assembly for the helmeted guinea fowl (HGF) to aid in understanding its domestication process in Africa.
- Genome analysis of 129 guinea fowl reveals domestication events occurred in West Africa approximately 1,300-5,500 years ago.
- Insights into genes related to behavior, locomotion, plumage color, and fertility were discovered, offering valuable resources for future research and breeding efforts.
Article Synopsis
- * Multi-omics analyses identified 35,960 genomic variants, as well as differences in proteins and miRNAs between affected and unaffected cats.
- * Key findings suggest that the disorder is complex rather than linked to a single gene mutation, with amyloid deposits arising from a mix of normal proteins, classifying it as AA amyloidosis.
Article Synopsis
- Heritage breeds serve as a crucial genetic resource, preserving genetic diversity and showcasing cultural significance, with potential for commercial enhancement through gene introgression.
- The research aims to analyze the genomic structure of four native Italian turkey breeds using Copy Number Variants (CNVs), identifying a total of 1,077 CNVs across 102 turkeys.
- Findings reveal differences in CNVs among the breeds related to their physiological and behavioral traits, and genomic comparisons indicate relationships based on geographical origins and historical development of rural areas in Italy.
Article Synopsis
- The Aosta Red Pied, Aosta Black Pied, and Aosta Chestnut are dual-purpose cattle breeds that thrive in harsh alpine environments, primarily grazing at high altitudes during the summer.
- A genetic study involving 728 cattle revealed distinct populations among the three breeds, utilizing tools like the GeenSeek Genomic Profiler® for genetic analysis and assessing inbreeding through Runs of Homozygosity (ROH).
- The genetic analysis showed low inbreeding levels (F values) for the breeds and identified specific genes linked to their ability to adapt to tough farming conditions, suggesting their unique traits valued by farmers.
Article Synopsis
- - The study investigates the quality differences in eggs from traditional hen breeds (Milanino, Mericanel della Brianza, Valdarnese Bianca) versus commercial hybrid strains by analyzing their physical and fatty acid properties, as well as related nutritional factors.
- - A total of 54 eggs were analyzed using General Linear Model and Principal Component Analyses to compare the characteristics of traditional vs hybrid eggs, revealing distinct differences in their physical and chemical parameters.
- - Results show that traditional breed eggs have a higher nutritional value due to better yolk content and healthier fatty acid ratios, while commercial hybrid eggs excel in commercial metrics like weight and edible content.
Article Synopsis
- The study compares the genomic characteristics of 30 Mexican turkeys, descended from original domesticated wild turkeys, with 38 commercial hybrid turkeys, using over 327,000 SNP markers to examine how different selection methods have affected their genomes.
- Findings revealed two distinct genetic clusters among Mexican turkeys, showing their differentiation from hybrids, with specific genomic regions (Runs of Homozygosity) linked to traits such as abdominal fat and egg characteristics.
- The results indicate that Mexican turkeys exhibit higher genomic variability due to adaptive selection, while hybrids show more genomic homogeneity resulting from strong directional selection practices over the past four decades.
Article Synopsis
- The German Shorthaired Pointer (GSHP) is recognized for its hunting skills and is popular as both a companion and athlete, leading to a study on its genetic structure and inbreeding levels.
- A total of 34 samples from Italy and the USA were analyzed, revealing 3183 runs of homozygosity (ROH) with a mean of 93.6 ROH per dog, indicating genetic diversity across all chromosomes.
- The genomic analysis showed a low inbreeding coefficient of 0.17 based on ROH, while genealogical data indicated an even lower inbreeding level of 0.023, suggesting a relatively healthy genetic pool for the breed.
Article Synopsis
- Embryos initially rely on RNAs from the oocyte until they activate their own genome, a process known as embryonic genome activation (EGA), while the role of sperm in influencing pre-EGA embryonic RNA is unclear.
- A study found 65 differentially expressed RNAs in bovine embryos from high and low fertility sires, with certain RNAs like PPP1R36 and ATXN2L showing significant patterns that could affect development.
- The research also identified a total of 472 sperm-derived RNAs, 2575 oocyte-derived RNAs, and additional unique RNAs, highlighting the contribution of male fertility and providing initial insights into the parental origin of RNAs before EGA.
Article Synopsis
- This study aimed to detect copy number variations (CNVs) in the Valle del Belice dairy sheep population and analyze their impact on milk production traits.
- The researchers genotyped 416 sheep using the Illumina OvineSNP50 BeadChip array, identifying 7,208 CNVs, which were aggregated into 365 CNVRs, with 31 found to be significantly associated with milk-related traits.
- A total of 222 genes were annotated within the significant CNVRs, indicating their potential roles in biological processes related to milk production and health, suggesting further research into these genes is warranted.
Article Synopsis
- Copy number variants (CNVs) are key genomic variations that can affect traits in various species, but previous studies on cattle have not extensively analyzed CNV patterns using high-density SNP arrays.* ! -
- In this study, researchers conducted a high-resolution CNV scan on the Valdostana Red Pied (VRP) cattle population using a powerful Beadchip and identified 6,784 CNVs across 108 bulls, revealing distinct losses and gains in genetic information.* ! -
- Comparisons revealed that the CNVs in VRP were more similar to those in the Italian Brown Swiss breed than to the Mexican Holstein, and analyses showed three separate clusters for the breeds, highlighting genetic differentiation potentially influenced by selective breeding
Mitochondrial DNA genetic diversity in six Italian donkey breeds (Equus asinus).
Maria Cristina Cozzi Paolo Valiati Raffaele Cherchi Erica Gorla Raphaelle Teresa Matilde Maria Prinsen Maria Giuseppina Strillacci
Mitochondrial DNA A DNA Mapp Seq Anal
April 2018
Donkeys have played an important role in agricultural land practices and in human historical periods of recent past and, still today, are used as a working power in several world areas. The objective of this study was to identify genetic variability in six Italian donkey breeds using mtDNA D-loop. Fifteen haplotypes, grouped in three haplogroups, were identified.
View Article and Find Full Text PDFArticle Synopsis
- The study looked at how tiny particles called microvesicles (MVs) from special stem cells help communicate with other cells and can assist in healing stressed cells in the womb.
- Researchers tested the MVs to see how effective they were in helping sick endometrial cells, especially when they were damaged by certain harmful substances.
- Results showed that these MVs can help the cells survive better, grow faster, and reduce inflammation, suggesting they might help reduce inflammation in endometrial tissue in real life.
Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in feedlot cattle, caused by multiple pathogens that become more virulent in response to stress. As clinical signs often go undetected and various preventive strategies failed, identification of genes affecting BRD is essential for selection for resistance. Selective DNA pooling (SDP) was applied in a genome wide association study (GWAS) to map BRD QTLs in Israeli Holstein male calves.
View Article and Find Full Text PDFThe genetic variability of the mitochondrial D-loop DNA sequence in seven horse breeds bred in Italy (Giara, Haflinger, Italian trotter, Lipizzan, Maremmano, Thoroughbred and Sarcidano) was analysed. Five unrelated horses were chosen in each breed and twenty-two haplotypes were identified. The sequences obtained were aligned and compared with a reference sequence and with 27 mtDNA D-loop sequences selected in the GenBank database, representing Spanish, Portuguese, North African, wild horses and an Equus asinus sequence as the outgroup.
View Article and Find Full Text PDF