Flecainide to Prevent Atrial Arrhythmia After Patent Foramen Ovale Closure: AFLOAT Study, A Randomized Clinical Trial.

Background: The real incidence of atrial arrhythmia (AA) after patent foramen ovale (PFO) closure and whether this complication can be prevented remain unknown. We assessed whether flecainide is effective to prevent AA during the first 3 months after PFO closure, and whether 6 months of treatment with flecainide is more effective than 3 months to prevent AA after PFO closure.

Methods: AFLOAT (Assessment of Flecainide to Lower the Patent Foramen Ovale Closure Risk of Atrial Fibrillation or Tachycardia Trial) is a prospective, multicentre, randomized, open-label, superiority trial with a blind evaluation of all the end points (PROBE [Prospective Randomized Open, Blinded End Point] design).

Using Evidence and Coalitions to Scale-Up a National Early Education Initiative: The Case of Law 248/2015 in Romania.

In 2015, Romania took an important step toward increasing disadvantaged children's participation in early education programmes through the passage of legislation creating a nationwide conditional cash transfer programme linked to preschool attendance. The programme was modeled on the incentive component of a 5-year pilot project "Every Child in Preschool" ("FCG") initiated by Asociatia OvidiuRo ("OvR"), a small non-governmental organization. This paper explores how OvR used evidence from its pilot, global research, a quasi-experimental evaluation, collaboration with local authorities, and an intensive advocacy effort toward the legislative and executive branches of the national government to achieve the national scale-up of an early education initiative designed to create equal access in kindergarten among Roma and other impoverished, marginalized children.