Publications by authors named "Maria Geysillene Castro Matos"
Quantum mechanical, molecular docking, molecular dynamics, ADMET and antiproliferative activity on (Y strain) of chalcone ()-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(3-nitrophenyl)prop-2-en-1-one derived from a natural product.
Maria Geysillene Castro Matos Leonardo Paes da Silva Francisco Wagner Queiroz Almeida-Neto Emanuelle Machado Marinho Ramon Róseo Paula Pessoa Bezerra de Menezes
Phys Chem Chem Phys
February 2022
Article Synopsis
- Recent research has focused on chalcones as potential new therapies, assessing their antiproliferative effects against Chagas' causative agent with promising results showing effectiveness at various concentrations.
- The studied chalcone exhibited a mechanism of action linked to mitochondrial damage and showed stronger affinity for the target enzyme cruzain than BZN, indicating its potential as an effective and less toxic treatment option.
In silico study of the potential interactions of 4'-acetamidechalcones with protein targets in SARS-CoV-2.
Francisco Wagner Q Almeida-Neto Maria Geysillene Castro Matos Emanuelle Machado Marinho Márcia Machado Marinho Ramon Róseo Paula Pessoa Bezerra de Menezes
Biochem Biophys Res Commun
January 2021
The sanitary emergency generated by the pandemic COVID-19, instigates the search for scientific strategies to mitigate the damage caused by the disease to different sectors of society. The disease caused by the coronavirus, SARS-CoV-2, reached 216 countries/territories, where about 20 million people were reported with the infection. Of these, more than 740,000 died.
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