Periodontal Ligament Reactions to Orthodontic Force: A Transcriptomic Study on Maxillary and Mandibular Human Premolars.

Aims: Orthodontic force (OF) induces a variety of reactions in the periodontal ligament (PDL) that could potentially account for individual variability regarding orthodontic tooth movement (OTM). This study investigates the transcriptomic profile of human PDL tissue subjected to OF in vivo for 7 and 28 days, additionally comparing the differences between maxillary and mandibular PDL.

Methods: Healthy patients requiring orthodontic premolar extractions were randomly assigned to one of three groups: control (CG) where no OF was applied, 7 days and 28 days, where premolars were extracted either 7 or 28 days after the application of a 50-100 g OF.

Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions.

Human 5'-3' exonuclease PLD3, a member of the phospholipase D family of enzymes, has been validated as a therapeutic target for treating Alzheimer's disease. Here, we have determined the crystal structure of the luminal domain of the enzyme at 2.3 Å resolution, revealing a bilobal structure with a catalytic site located between the lobes.

Effect of Human Adenovirus Type 35 Concentration on Its Inactivation and Sorption on Titanium Dioxide Nanoparticles.

Removal of pathogenic viruses from water resources is critically important for sanitation and public health. Nanotechnology is a promising technology for virus inactivation. In this paper, the effects of titanium dioxide (TiO) anatase nanoparticles (NPs) on human adenovirus type 35 (HAdV-35) removal under static and dynamic (with agitation) batch conditions were comprehensively studied.

Wildfire and African dust aerosol oxidative potential, exposure and dose in the human respiratory tract.

Exposure to wildfire smoke and dust can severely affect air quality and health. Although particulate matter (PM) levels and exposure are well-established metrics linking to health outcomes, they do not consider differences in particle toxicity or deposition location in the respiratory tract (RT). Usage of the oxidative potential (OP) exposure may further shape our understanding on how different pollution events impact health.

Treatment outcome of partial pulpotomy using two different calcium silicate materials in mature permanent teeth with symptoms of irreversible pulpitis: A randomized clinical trial.

Aim: To assess the clinical and radiographic outcome of partial pulpotomy by comparing MTA Angelus and Total Fill BC, as pulpotomy agents, in mature teeth with deep caries and symptoms indicative of irreversible pulpitis.

Methodology: The study was designed as a parallel-two arm, double-blind, randomized superiority clinical trial registered at www.

Clinicaltrials: gov (NCT04870398).

Outcome of Partial Pulpotomy in Immature Permanent Teeth with Symptomatic Irreversible Pulpitis: A Prospective Case Series Assessment.

Introduction: The aim of this prospective case series was to assess the clinical and radiographic outcome of partial pulpotomy in caries-exposed symptomatic, vital, immature, permanent molars.

Methods: Thirty-four immature molars with deep caries and symptoms of irreversible pulpitis were treated by partial pulpotomy and ProRoot MTA as a capping material. After complete caries removal, the inflamed part of the pulp was removed.

A beneficial fungal root endophyte triggers systemic RNA silencing and DNA methylation of a host reporter gene.

A growing body of evidence suggests that RNA interference (RNAi) plays a pivotal role in the communication between plants and pathogenic fungi, where a bi-directional trans-kingdom RNAi is established to the advantage of either the host or the pathogen. Similar mechanisms acting during plant association with non-pathogenic symbiotic microorganisms have been elusive to this date. To determine whether root endophytes can induce systemic RNAi responses to their host plants, we designed an experimental reporter-based system consisting of the root-restricted, beneficial fungal endophyte, strain K (FsK) and its host .

The role of nanoparticles (titanium dioxide, graphene oxide) on the inactivation of co-existing bacteria in the presence and absence of quartz sand.

The increased mass production and application of engineered nanomaterials (ENMs) have resulted in the release of nanoparticles (NPs) in the environment, raising uncertainties regarding their environmental impacts. This study examines the effect of graphene oxide (GO) and titanium dioxide (TiO) NPs on the inactivation of the three model bacteria originated by mammalians including humans: Escherichia (E.) coli, Enterococcus (E.

Evaluating the knowledge level, attitudes, and therapeutic approaches of Greek dentists for traumatic dental injuries.

Background/aim: Greek dentists are facing a new era of a globally continuous effort to improve the first-aid management and long-term treatment outcome of traumatic dental injuries (TDI). In Greece, where the basic and clinical research in the field of dental trauma has been limited until recently, assessing the attitudes and therapeutic strategies of Greek dentists for dental trauma is of great importance. The aim of this study was to evaluate the knowledge attitudes and therapeutic approaches of Greek dentists in different clinical scenarios of TDI.

Influence of graphene oxide nanoparticles on the transport and cotransport of biocolloids in saturated porous media.

This study examines the effect of graphene oxide (GO) nanoparticles (NPs) on the transport (individual species) and cotransport (simultaneous transport) of three biocolloids (Escherichia (E.) coli, Enterococcus (E.) faecalis and Staphylococcus (S.

Lotus SHAGGY-like kinase 1 is required to suppress nodulation in Lotus japonicus.

Glycogen synthase kinase/SHAGGY-like kinases (SKs) are a highly conserved family of signaling proteins that participate in many developmental, cell-differentiation, and metabolic signaling pathways in plants and animals. Here, we investigate the involvement of SKs in legume nodulation, a process requiring the integration of multiple signaling pathways. We describe a group of SKs in the model legume Lotus japonicus (LSKs), two of which respond to inoculation with the symbiotic nitrogen-fixing bacterium Mesorhizobium loti.

IgA nephropathy in Greece: data from the registry of the Hellenic Society of Nephrology.

Background: Natural history, predisposing factors to an unfavourable outcome and the effect of various therapeutic regimens were evaluated in a cohort of 457 patients with immunoglobulin A nephropathy (IgAN) and follow-up of at least 12 months.

Methods: Patients with normal renal function and proteinuria <1 g/24 h as well as those with serum creatinine (SCr) >2.5 mg/dL and/or severe glomerulosclerosis received no treatment.

Assessment of Fatigue in End Stage Renal Disease Patients Undergoing Hemodialysis: Prevalence and Associated Factors.

Background: Fatigue is a common symptom referred by many patients undergoing hemodialysis. Fatigue is associated with poor health-related quality of life (HRQoL) and is an important predictor for survival of hemodialysis patients.

Aim: To assess the levels of fatigue and demographic factors affecting it among patients with End Stage Renal Disease undergoing hemodialysis.

Hypertension in the elderly.

The elderly are the most rapidly growing population group in the world. Data collected over a 30-year period have demonstrated the increasing prevalence of hypertension with age. The risk of coronary artery disease, stroke, congestive heart disease, chronic kidney insufficiency and dementia is also increased in this subgroup of hypertensives.

Influence of specialty training and experience on endodontic decision making.

Introduction: The purpose of this study was to compare decision-making choices among dentists with different levels of training.

Methods: Scanned periapical radiographs and a leaflet with relevant information of 17 endodontically treated teeth were mailed to 40 undergraduate students, 25 general practitioners, 20 postgraduate students, and 40 endodontists. All teeth were symptom-free.

Periapical status and quality of root canal fillings and coronal restorations in a Greek population.

Objective: To investigate the quality of root canal fillings and coronal restorations in relation to periapical status in a Greek population.

Method And Materials: A total of 320 patients who required full-mouth radiographic examination were included. The quality of root canal fillings and the periapical status, as well as the quality of coronal restorations, were assessed by radiographic criteria.

Fluid filtration evaluation of 3 obturation techniques.

Objective: To evaluate coronal leakage and apical material extrusion of 3 obturation techniques.

Method And Materials: The coronal part of 60 freshly extracted human maxillary central incisors was removed, leaving roots 10 mm in length. After instrumentation by hand K-files and smear layer removal, the 60 roots were divided randomly into 3 groups.