NTRK Gene Fusion Detection in Atypical Spitz Tumors.

Atypical Spitz tumors (AST) deviate from stereotypical Spitz nevi for one or more atypical features and are now regarded as an intermediate category of melanocytic tumors with uncertain malignant potential. Activating fusions elicit oncogenic events in Spitz lesions and are targetable with kinase inhibitors. However, their prevalence among ASTs and the optimal approach for their detection is yet to be determined.

A Rare Case of Hydrocystoma of the Labial Commissure: Histopathology and Clinical Picture.

Objective: Hydrocystomas (HCs) are rare, benign, skin adnexal cystic tumors that may be either eccrine or apocrine.

Background Data: Apocrine-HCs are cystic lesions that arise from the apocrine secretory coil, whereas eccrine-HCs are retention cysts of the eccrine duct. The commonest site is around the eyes, on the ears, scalp, chest, shoulders, or feet; HCs of the oral cavity are very rare.

The Role of Fine Needle Aspiration of Orbital Lesions: A Case Series.

Objective: This paper analyzes a series of ultrasound (US)-guided orbital fine needle aspirations (FNAs) which provide diagnostic information that cytopathologists approaching orbital lesions for the first time can find useful and underlines the importance of teamwork.

Study Design: The investigators retrospectively obtained data from 24 consecutive orbital FNAs. For all patients, a complete clinicoradiological database was created.

A rare case of synovial chondromatosis of the inferior TMJ compartment. Diagnosis and treatment aspect.

Aim: Synovial Chondromatosis (SC) is a rare, benign non neoplastic arthopathy characterized by the metaplastic development of cartilaginous nodules within the synovial membrane. In only 3% of all cases does it affect the temporomandibular joint (TMJ) and cases that arise from the lower compartment are rarely found in literature. The aim of this paper is to report a new case of SC of the inferior TMJ compartment with the description of the clinical, therapeutic and histopathological findings.

Clinical and histopathological profile of primary or secondary osteosarcoma of the jaws.

Osteosarcoma of the jaw is a rare disease; we report two cases, one in which the primary osteosarcoma had occurred in the sacrum and ileum, the second at the mandible. Dissemination of osteosarcoma to other organs, especially early dissemination to the lung, is common, but metastasis to the jaw has only rarely been reported. About 10% of osteosarcomas occur in the head and neck, most in the mandible or maxilla.

Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features.

Aims: Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland neoplasm that most commonly occurs in the parotid gland, but can also arise in the minor salivary glands. Three cases are reported of epithelial-myoepithelial carcinoma of the minor salivary glands, with the goal of better defining this entity.

Patients And Methods: All three cases showed a characteristic nodular/multinodular growth pattern and classic biphasic tubular histology.

Perianal condyloma-like lesions in multiple myeloma associated amyloidosis.

Systemic types of amyloidosis include those associated with plasma cell dyscrasia, as in multiple myeloma. Here we describe a 57-year-old woman who was diagnosed as having multiple myeloma IgG lambda. Six months after the diagnosis of myeloma, mucocutaneous lesions began to develop, with ecchymoses in the body folds and eyelid and periorbital purpura.