Reproductive effects after exposure of male mice to vincristine and to a combination of X-rays and vincristine.

This study was performed to investigate the effects of exposure to vincristine (VCR) alone (1 mg kg(-1) or 2 mg kg(-1)) and in combination with X-rays (0.25 Gy + 1 mg kg(-1) VCR or 1.00 Gy + 2 mg kg(-1) VCR) on the quality and quantity of spermatozoa, and the offspring of exposed Pzh : Sfis male mice.

[The change in reproductive ability of male mice exposed to vinblastine and X-rays].

The effects of male mice to vinblastine (VBL) and combined X-rays-vinblastine treatments on the sperm quantity and quality, fertility and induction of foetal deaths and congenital malformations in the offspring were investigated. VBL and combined X-rays-VBL exposure caused decrease in testes weight and sperm count as well as increased percent of abnormal spermatozoa. Both vinblastine and X-rays-vinblastine combination induced increase in frequency of DNA single strand breaks in germ cells.