Publications by authors named "Maria G Juarez"
Article Synopsis
- - The study focuses on developing a nanoparticle (NP) vaccine for respiratory syncytial virus (RSV), specifically comparing a wild-type RSV G protein to a modified version (S177Q) that shows improved immune response.
- - Mice immunized with the NP-S177Q vaccine generated stronger immune responses, producing more neutralizing antibodies and showing better protection against RSV challenges compared to the wild-type.
- - While the NP-S177Q vaccine shows promise, the overall NP vaccine platform needs enhancements due to issues with solubility and a weaker than expected Th1 immune response.
A central problem in human biology remains the discovery of causal molecular links between mutations identified in genome-wide association studies (GWAS) and their corresponding disease traits. This challenge is magnified for variants residing in non-coding regions of the genome. Single-nucleotide polymorphisms (SNPs) in the 5' untranslated region (5'-UTR) of the ferritin light chain () gene that cause hyperferritinemia are reported to disrupt translation repression by altering iron regulatory protein (IRP) interactions with the mRNA 5'-UTR.
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