Publications by authors named "Maria G Giuliano"
Article Synopsis
- - The study reveals that the RtcR CARF domain regulates two important RNA repair enzymes, RtcA and RtcB, which are necessary for activating transcription.
- - RtcA and RtcB interact directly with RtcR, but while RtcAB’s catalytic activity is essential for transcription activation, it alone doesn’t suffice, suggesting another activating signal is required.
- - This additional signal seems to come from the translation machinery, as RtcB repairs tmRNA, enhancing ribosome function and indicating CARF domain signaling has broader implications involving RNA repair and translation.
Since the early description of Randall plaques in 1937, studies of the pathogenesis of stone formation mainly focused on the chemistry involving salt precipitation and crystallization, rather than tubular and interstitial medullar mechanisms of calcium concentration and supersaturation. In 2003, Bushinsky published a suggestive and inspiring sequence of events aimed to show that the basement membrane of the thin limb of the loop of Henle can be the first site of nucleation, as recently shown by the impressive work by Evan et al. The aim of this minireview is to verify the consistency of the Evan and Bushinsky theory with the current literature in the field.
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