Quality Management System in Clinical Digital Pathology Operations at a Tertiary Cancer Center.

Digital pathology workflows can improve pathology operations by allowing reliable and fast retrieval of digital images, digitally reviewing pathology slides, enabling remote work and telepathology, use of computer-aided tools, and sharing of digital images for research and educational purposes. The need for quality systems is a prerequisite for successful clinical-grade digital pathology adoption and patient safety. In this article, we describe the development of a structured digital pathology laboratory quality management system (QMS) for clinical digital pathology operations at Memorial Sloan Kettering Cancer Center (MSK).

Changes in the Diagnoses of Breast Core Needle Biopsies on Second Review at a Tertiary Care Center: Implications for Surgical Management.

Core needle biopsy (CNB) of breast lesions is routine for diagnosis and treatment planning. Despite refinement of diagnostic criteria, the diagnosis of breast lesions on CNB can be challenging. At many centers, including ours, confirmation of diagnoses rendered in other laboratories is required before treatment planning.

Validation of a digital pathology system including remote review during the COVID-19 pandemic.

Remote digital pathology allows healthcare systems to maintain pathology operations during public health emergencies. Existing Clinical Laboratory Improvement Amendments regulations require pathologists to electronically verify patient reports from a certified facility. During the 2019 pandemic of COVID-19 disease, caused by the SAR-CoV-2 virus, this requirement potentially exposes pathologists, their colleagues, and household members to the risk of becoming infected.

Hormone receptor and HER2 assessment in breast carcinoma metastatic to bone: A comparison between FNA cell blocks and decalcified core needle biopsies.

Background: Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) guide the clinical management of breast cancer metastases. Decalcification of bone core needle biopsies (CNBs) can affect IHC. In the current study, the authors sought to define whether fine-needle aspiration (FNA) would be a better alternative to CNB for reliable IHC.

Accuracy of Intraoperative Frozen Section of Sentinel Lymph Nodes After Neoadjuvant Chemotherapy for Breast Carcinoma.

False-negative (FN) intraoperative frozen section (FS) results of sentinel lymph nodes (SLN) have been reported to be more common after neoadjuvant chemotherapy (NAC) in the primary surgical setting. We evaluated SLN FS assessment in breast cancer patients treated with NAC to determine the FN rate and the histomorphologic factors associated with FN results. Patients who had FS SLN assessment following NAC from July 2008 to July 2017 were identified.

Voices from the Field: Supporting the Educational Needs of Cytotechnologists.

Introduction: Sustaining a well-trained, competitive, and marketable cytotechnology workforce is a major goal of the American Society of Cytopathology/American Society for Clinical Pathology Workgroup Focusing on Emerging Roles in Cytopathology (ASC/ASCP Workgroup). This article describes the data collection initiatives performed by the Workgroup to confirm cytotechnologist (CT) perceived educational needs to keep pace with emerging practice changes in the workplace. In response to data collected, the Workgroup created Advanced Cytopathology Education (ACE)da unique, innovative educational resource designed to fulfill this need.

Perspectives on Expanded Scope of Practice in Cytotechnology.

Introduction: In an effort to identify professional trends while offering meaningful resources to support decision making in the cytopathology community, the ASC/ASCP Workgroup: Focusing on Emerging Roles in Cytopathology conducted several data collection activities to assess the current state and professional trends of cytotechnologist (CT) practice. This information is intended to inform evidence- based development of education and workforce model(s).

Materials And Methods: Research was conducted through mixed-method data collection processes.

Voices from the field: supporting the educational needs of cytotechnologists.

Introduction: Sustaining a well-trained, competitive, and marketable cytotechnology workforce is a major goal of the American Society of Cytopathology/American Society for Clinical Pathology Workgroup Focusing on Emerging Roles in Cytopathology (ASC/ASCP Workgroup). This article describes the data collection initiatives performed by the Workgroup to confirm cytotechnologist (CT) perceived educational needs to keep pace with emerging practice changes in the workplace. In response to data collected, the Workgroup created Advanced Cytopathology Education (ACE)-a unique, innovative educational resource designed to fulfill this need.

Perspectives on expanded scope of practice in cytotechnology.

Introduction: In an effort to identify professional trends while offering meaningful resources to support decision making in the cytopathology community, the ASC/ASCP Workgroup: Focusing on Emerging Roles in Cytopathology conducted several data collection activities to assess the current state and professional trends of cytotechnologist (CT) practice. This information is intended to inform evidence-based development of education and workforce model(s).

Materials And Methods: Research was conducted through mixed-method data collection processes.

Novel Modification of HistoGel-Based Cell Block Preparation Method: Improved Sufficiency for Molecular Studies.

Context: - Cell block preparation methods vary substantially across institutions and are frequently suboptimal. The growing importance of biomarker testing in the era of targeted therapies makes optimization of cell block preparation critically important.

Objective: - To develop an improved cell block preparation method.

Cytologic assessment of estrogen receptor, progesterone receptor, and HER2 status in metastatic breast carcinoma.

Background: Discordance in the receptor status between primary breast carcinomas (PBC) and corresponding metastasis is well documented. Interrogation of the receptor status of metastatic breast carcinoma (MBC) in cytology material is common practice; however, its utility has not been thoroughly validated. We studied patients with MBC, and evaluated the concordance rates of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between PBC surgical specimens and corresponding MBC cell blocks (CBs).

Bethesda Interobserver Reproducibility Study-2 (BIRST-2): Bethesda System 2014.

Introduction: In concert with the 2014 update to the Bethesda System for Reporting Cervical Cytology, a Web-based image interobserver study was performed to evaluate concordance with the "expert panel" interpretation, as was done during the Bethesda 2001 update. The aim was to identify cytomorphologic features and Bethesda reporting categories that represent sources of poor interobserver agreement and see how the trends compared to the first Bethesda Interobserver Reproducibility Study (BIRST).

Materials And Methods: Participants were recruited online through national and international cytopathology professional societies.

Cytology workforce study: a report of current practices and trends in New York State.

A survey was conducted among 130 New York State (NYS) registered cytology laboratories to better understand current and future changes in the practice of cytology, changes in the cytotechnologist (CT) scope of practice, and the future need for CTs. A 51.5% (67/130) response rate was obtained.

Suitability of thoracic cytology for new therapeutic paradigms in non-small cell lung carcinoma: high accuracy of tumor subtyping and feasibility of EGFR and KRAS molecular testing.

Introduction: The two essential requirements for pathologic specimens in the era of personalized therapies for non-small cell lung carcinoma (NSCLC) are accurate subtyping as adenocarcinoma (ADC) versus squamous cell carcinoma (SqCC) and suitability for EGFR and KRAS molecular testing. The aim of this study was to comprehensively review the performance of cytologic specimens for the above two goals in a high-volume clinical practice.

Methods: Subtyping of primary lung carcinomas by preoperative cytology was correlated with subsequent resection diagnoses during a 1-year period (n = 192).

[Professional satisfaction of the nurse professor: a qualitative study].

The aim of this study was to recognize the satisfaction of the nurse professor of the nursing graduation course and to identify factors which, according to the professors, interfere in this state of satisfaction. Semi-structured interviews were performed with eight nurse professors from an official nursing school in the city of São Paulo. The results were analyzed according to the plan of the content analysis proposed by Bardin, under a qualitative approach.

Diagnostic pitfalls in fine needle aspiration biopsy of the spleen.

Fine needle aspiration (FNA) of the spleen is rarely performed, due to fear of procedure complications. The objective of this study is to review the cytologic diagnoses of aspiration biopsy of the spleen performed in a cancer center. Archival material (9-year period) was reviewed and correlated with histologic and ancillary test results, when available.

Effectiveness of the Thin Prep Imaging System in the detection of adenocarcinoma of the gynecologic system.

Background: The ThinPrep Imaging System (TIS) has been approved by the U.S. Food and Drug Administration for use to decrease the number of false-negative results in ThinPrep (TP) gynecologic specimens and increase cytotechnology productivity.

[Analysis of a scientific article: an exercise].

This essay describes the analysis of a scientific article, with the purpose of demonstrating the operability of that activity, common for all the high level professionals, especially researchers. 23 items were selected as the most relevant ones in this type of analysis, and each item, besides describing some analysis criteria, also used a selected scientific article to exemplify the analysis. It concludes that the analysed scientific study was well prepared and with high quality.

[Nurse's training: professor's characteristics and academic success].

The present report describes the characteristics of the professor who teaches the disciplines that obtained the highest success indexes in the evaluation carried out by the students. It was executed at a Nursing Superior Education School in Lisbon (Portugal), regarding 16 professors who answered a questionnaire. We concluded that a professor who is well evaluated by the students has the following attributes: he is mature, well qualified for education, with a solid experience in teaching and a good experience in the exercise of the profession.

Fine needle aspiration biopsy of primary mucinous carcinoma of the skin: a case report.

Background: Primary mucinous carcinoma of the skin is a rare neoplasm of sweat gland origin. To date there are only 2 case reports in English describing its features on fine needle aspiration biopsy (FNAB). We describe an additional case and review the literature regarding this entity.

Anorectal cytology as a screening tool for anal squamous lesions: cytologic, anoscopic, and histologic correlation.

Background: Anorectal cytology has been increasingly used as a screening method for anal squamous lesions, particularly in high-risk, homosexual, patients with human immunodeficiency virus infection. The diagnostic cytologic, anoscopic, and histologic criteria bear some resemblance to the criteria used in cervicovaginal samples with few differences. It is important to recognize these differences because they can lead to an erroneous diagnosis of dysplasia and unnecessary procedures.

[Nursing publication - a survey of priorities].

The Special Comission on Text-Book of the Nursing Brasilian Association (ABEn) developed a survey to stablish priorities for nursing publication in Brazil. A questionnaire was sent to three teachers of every brazilian school of nursing and the following subjects were emphasized: areas that needed coverage; difficulties encountered by professors in the edition of nursing texts; and their preference for available vehicles. 47,6% of the schools returned the questionnaires, but only 39,5% of the professors answered.

[The used of the nursing laboratory by nursing students].

The authors describle the results of a small survey of the students' training for in the Nursing Laboratory of the School of Nursing the improvment of their psychomotor hability classroom laboratory. The students answered questions on the motivation for the use of the Laboratory, preferences for training alone or with classmates and for using the doll or a classmate to simulate the patient, the monitoring of a senior student, the bibliography used and the procedures selected for training.

[The learning of basic nursing procedures a comparision of two methods].

A comparision of the learning of basic nursing procedures was experimentally investigated. The main objectives were: a) to verify it students trained in nursing laboratory make less mistakes in their first real situation than those who had not similar training; b) to evaluate mursin laboratory training through a self-instructional strategy as compared with the traditional strategy. Sixty-four female students enrolled in the Fundamentals of Nursing Course were investigated They had no prior experience with bladder catheterization.

[Students as proctors: a experience in Fundamental of Nursing].

Three advanced students were used as proctors in Fundamentals of Nursing for the academic periods of 1981 and 1982. Results are presented and the opinions of both, the proctors and oriented students, are discussed.