Publications by authors named "Maria Francesca Petrucci"
Front Immunol
September 2024
Article Synopsis
- Ischemia/reperfusion injury (IRI) occurs when blood flow is restored after a period of interrupted supply, leading to inflammatory responses and neutrophil recruitment that release NETs (neutrophil extracellular traps).
- In a study on pig forelimbs, researchers examined the effects of different durations of ischemia (1 hour vs. 9 hours) and monitored various indicators of tissue damage and NET formation.
- Findings indicated that longer ischemia worsens damage, with a significant increase in NETs and citrullinated fibrinogen levels in the 9-hour ischemia group compared to the 1-hour group, highlighting the detrimental role of NETs in IRI.
Article Synopsis
- The current standard for preventing rejection in vascularized composite allotransplantation (VCA) uses systemic immunosuppression, which poses significant side effects, leading to interest in local immunosuppression methods.
- Researchers investigated a local drug delivery system for tacrolimus (TGMS-TAC) to reduce toxicity and enhance graft survival, showing promising results in a porcine model, although some rejection signs were noted.
- Results indicated that while systemic immune responses remained stable, local tissue analysis revealed infiltration of immune cells and involvement of neutrophil extracellular traps (NETs) in the rejection process, highlighting the need for better understanding of VCA graft rejection mechanisms.
