Effects of intravitreal ranibizumab on the untreated eye and systemic gene expression profile in age-related macular degeneration.

The purpose of this study was to evaluate the systemic effects of intravitreal ranibizumab (Lucentis) treatment in patients with neovascular age-related macular degeneration (AMD). The impact of intravitreal ranibizumab injections on central retinal thickness (CRT) of treated and contralateral untreated eyes, and differences in gene expression patterns in the peripheral blood mononuclear cells were analyzed. The study included 29 patients aged 50 years old and over with diagnosed neovascular AMD.

Nonpenetrating very deep sclerectomy with hyaluronic acid implant vs trabeculectomy--a 2-year follow-up.

Objective: To study and compare the efficacy and safety of nonpenetrating very deep sclerectomy (NPVDS) with the use of hyaluronic acid implant (SKGEL) to trabeculectomy (TB) in patients with with medically uncontrolled glaucoma.

Methods: Prospective, controlled study of patients with open-angle glaucoma was designed. Seventy-eight eyes of 68 patients with medically uncontrolled glaucoma were assigned either to the NPVDS or to the TB group of trial.

Quantitative relationships between transforming growth factor beta mRNA isoforms in congenital and traumatic cataracts.

Purpose: The aim of this study was to determine differences in the expression profiles of transforming growth factor (TGF) β isoforms in the fragments of anterior lens capsules (ALCs) and peripheral blood mononuclear cells (PBMCs) of pediatric patients with congenital and traumatic cataracts.

Methods: Forty children with congenital cataracts (19 girls and 21 boys) and 22 children with traumatic cataracts (six girls and 16 boys) participated in the study. Fragments of ALCs obtained during cataract surgery and whole blood samples were analyzed.

Etiopathogenesis and management of high myopia. Part II.

High myopia (HM) is defined as refractive error above -6.0 D (-8.0 diopters) with axial eyeball length above 26 mm, and is connected with the process of excessive myopisation.

Etiopathogenesis and management of high-degree myopia. Part I.

High-degree myopia (HM) is defined as a refractive error above -6 D (-8 diopters). An axial eyeball length above 26 mm and is also connected with excessive myopisation. Mechanical stretching and thinning of the choroids may lead to the development of irreversible degenerative changes in the eyeball and visual impairment.

Contact transscleral cyclophotocoagulation in the treatment of neovascular glaucoma: a five-year follow-up.

Background: The purpose of the study was to evaluate the long-term efficacy of contact transscleral cyclophotocoagulation (TSCPC) performed after panretinal photocoagulation and cryoapplication in patients with angle closure neovascular glaucoma.

Material/methods: Thirty eyes of 30 patients with angle closure neovascular glaucoma were enrolled (15 women and 15 men, mean age: 55+/-21 years). Diode TSCPC was performed in all patients after panretinal photocoagulation and cryotherapy.

Nonpenetrating very deep sclerectomy with reticulated hyaluronic acid implant in glaucoma treatment.

Background: The purpose of our study was to assess intraocular pressure control (IOP) and postoperative complications in nonpenetrating very deep sclerectomy (NPVDS) with reticulated hyaluronic acid implant (SKGEL) and Mitomycin C (MMC).

Material/methods: Fifty eyes from fifty patients with medically uncontrolled glaucoma were randomized to either the NPVDS or NPDS group. The NPVDS procedure was similar to traditional NPDS (control group); however, excision of sclera and exposure of ciliary body were also performed, and only a narrow scleral flap was retained at a distance of 0.

Atypical features of dementia in a patient with Creutzfeldt-Jakob disease.

Background: This article describes a Polish patient (female, right-handed, age 68 at onset) diagnosed with the Heidenhain variant of Creutzfeldt-Jakob Disease (HvCJD), characterized clinically by isolated visual disturbances with no ocular dysfunction prior to the development of myoclonus and other symptoms of CJD.

Case Report: Nothing in the history pointed to iatrogenic or acquired CJD, and genetic testing ruled out familial CJD. The neuroradiological picture (MRI) showed non-specific features of cerebral atrophy (cortical and subcortical).

[Necrotic central retinitis due to the lupus erythematosus].

We present a case of a twenty six years old patient who had been treated for systemic lupus erythematosus (SLE) for five years. The patient developed a sudden significant disturbance of vision quality of both eyes. A lot of additional examinations were done and central necrotic retinitis was diagnosed.

[Diode laser in secondary glaucoma in children--long-term results].

Unlabelled: This paper presents effectiveness and safety of transscleral contact cyclophotocoagulation with diode laser (TSCPC) in secondary glaucoma in children. Fifteen eyes of 15 children at the age from 4 to 18 years were examined. Majority of patients was aphakic after congenital and traumatic cataract extraction.

[Assessment of blood flow in retinal pigment degeneration].

Degeneratio pigmentosa retinae (RP) is one of the most common inherited retinal disease. The authors analyzed the blood flow in the central retinal artery using the DRG Retina Doppler. The blood flow velocity depending on the perimetry was also measured.

[The state of the visual system in the isolated form of retinitis pigmentosa or in Usher syndrome considering examination of retinal blood flow in the middle retinal artery with Doppler].

In this paper the authors compare a group of patients suffering from isolated form of retinitis pigmentosa with these with Usher syndrome.

Transscleral cyclophotocoagulation in the treatment of secondary glaucoma.

Background: The purpose of this study was to evaluate the results obtained by using transscleral cyclophotocoagulation (TSCPC) in the treatment of refractory secondary glaucoma. Our study attempted to assess the functional effects of TSCPC in different types of secondary glaucoma.

Material/methods: We studied 83 eyes in 81 patients: 52 men and 29 women, aged 9-88 years old (mean 52.

[Retrospective evaluation of eyes with high progressive myopia in children and youth ten years after Snyder and Thompson's scleroplasty].

Purpose: Of the study was, to assess the safety and efficiency of scleral reinforcement after Snyder and Thompson surgery.

Material And Methods: The scleroplasty was performed on 129 eyes of 75 children with progressive myopia from 6 to 10 years of age. The control study group included 40 eyes of 25 children with similar age, mean eyeball axial length and refraction.

The course of vision disturbances in a patient with the MELAS syndrome.

Background: This article describes the neuropsychological and ophthalmic symptoms presented by a patient with MELAS, a mitochondrial cytopathy. This rare disease is characterized by a remitting-relapsing course against the background of a slowly progressive degenerative process.

Case Report: The patient is a 22-year-old Polish female, with initial onset of symptoms in 1994; the clinical diagnosis of MELAS was established in 1998, and confirmed in 2000 by the discovery of a novel mtDNA mutation.