Schizophrenia is a chronic and severe pathology that is characterized by the presence of delusions, hallucinations, negative symptoms, disorganization of thought and behavior. Although its prevalence in children under 13 years of age is very low, it increases substantially during the adolescence. When it develops before 18 years of age, it is called early-onset schizophrenia and represents 12-33 % of all individuals with this disorder.
View Article and Find Full Text PDFIn the paediatric population, paticulary in the field of child and adolescent psychiatry, off-label indications are the rule rather than the exception. This may occur when a drug is indicated for a pathology, age, route of administration or treatment length other than those described in the product label. Argentina, unlike other countries, has no explicit regulation on off-label prescribing.
View Article and Find Full Text PDFRisperidone is an antipsychotic commonly used during pregnancy. Because it can cross the placental barrier, our objective was to evaluate its actions on the smooth muscle of the human umbilical artery (HUA). Risperidone preincubation (1-300 nmol/L for 20 minutes) produced a significant decrease in maximum force development induced by serotonin or histamine in HUA rings.
View Article and Find Full Text PDFThis study explores the effects of light maternal ethanol consumption during pregnancy on the appearance of minor malformations in neonates as well as on the contractile properties of their umbilical cord arteries (UCAs). Clinical external findings of newborns of women declaring light ethanol consumption during any period of their pregnancies [ethanol-exposed group (E group), n=79] were compared with those of nonexposed mothers [nonexposed to ethanol group (NE group), n=100]. Women who smoked or had any associated pathology were excluded.
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