Publications by authors named "Maria Florencia Fernandez"

3-indoxyl sulfate (3-IS) results from a hepatic transformation of indole, a tryptophan degradation product produced by commensal gut bacteria. The metabolite has shown promise as a biomarker of dysbiosis and clinical outcomes following hematopoietic stem cell transplant (HSCT) in adults. Nonetheless, there is a paucity of data regarding microbiome health and outcomes in the pediatric HSCT setting.

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Objectives: Immunosuppressive strategies for intestinal transplant have changed over time. However, specific intestinal transplant-oriented protocols and reports on long-term maintenance regimens are scarce. Our objective was to evaluate the impact of 2 different initial immunosuppressive protocols based on thymoglobulin (group A) and basiliximab (anti-interleukin 2 antibody) (group B) and of changes to maintenance immunosuppression over long-term follow-up in intestinal transplant recipients.

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Article Synopsis
  • Epidermolysis bullosa (EB) is a rare genetic disorder causing fragile skin and painful blisters, leading to serious complications like chronic wounds and squamous cell carcinoma.
  • The EASE study was a phase III trial that tested Oleogel-S10, a topical gel with birch triterpenes, for improving wound healing in patients with different forms of EB.
  • Results showed that 41.3% of patients using Oleogel-S10 achieved complete wound closure within 45 days, compared to 28.9% with a control gel, indicating that Oleogel-S10 is effective and well-tolerated for treating wounds in EB patients.
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At present, different reports have shown that children reach similar SARS-CoV-2 viral load (VL) levels compared to adults; however, the impact of VL on children remains ambiguous when asymptomatic versus symptomatic cases are compared. Thus, the aim of this study was to assess VL at the time of diagnosis in asymptomatic and symptomatic SARS-CoV-2 infected children. VL analysis was retrospectively carried out from nasopharyngeal swabs on 82 SARS-CoV-2 infected children, from March to October 2020.

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Dystrophic epidermolysis bullosa (DEB) is a clinically heterogeneous heritable skin disorder, characterized by blistering of the skin and mucous membranes following minor trauma. Dominant (DDEB) and recessive (RDEB) forms are caused by pathogenic variants in COL7A1 gene. Argentina's population has a heterogeneous genetic background, and little is known about the molecular basis of DEB in our country or in native South American populations.

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Coronavirus disease 2019 (COVID-19) is spreading throughout the world. Limited data are available for the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load (VL) in immunocompromised pediatric patients. Here, we report the clinical characteristics and the dynamics of SARS-CoV-2 VL of a pediatric patient with acute myeloid leukemia who developed a hyperinflammatory status mimicked MIS-C.

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Article Synopsis
  • Researchers studied how the HIV-1 V3 loop affects which co-receptors the virus can use, focusing primarily on subtype F, which hasn't been well-explored compared to other subtypes like B, C, and A.
  • They developed new bioinformatic tools to predict co-receptor usage in subtype F based on the genetic sequences of 40 newly analyzed V3 loops from different HIV-1 strains known for their ability to induce syncytia.
  • The findings reveal important genetic interactions that could enhance prediction accuracy for co-receptor usage in subtype F, which may aid in creating better prevention and treatment strategies for HIV-1 globally.
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Tungiasis, is a cutaneous parasitosis, native of America caused by Tunga penetrans. Infestations usually presents with black papular lesions, either single or multiple, most of them localized on the feet, mainly in the subungual and periungual areas. Diagnosis of tungiasis is based on the characteristic aspect of the lesions in a patient coming from an endemic area.

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