Publications by authors named "Maria Flenley"
Background: The mechanism by which protein complexes interact to regulate the deposition of post-translational modifications of histones remains poorly understood. This is particularly important at regulatory regions, such as CpG islands (CGIs), which are known to recruit Trithorax (TrxG) and Polycomb group proteins. The CxxC zinc finger protein 1 (CFP1, also known as CGBP) is a subunit of the TrxG SET1 protein complex, a major catalyst of trimethylation of H3K4 (H3K4me3).
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- The study explores how DNA sequences influence the chromatin state in cells, revealing gaps in the current understanding of this relationship.
- Researchers compare DNA regions in human and mouse cells to investigate why Polycomb complex recruitment occurs in human stem cells but not in mice.
- Findings indicate that local DNA sequences primarily encode chromatin state, with a high density of unmethylated CpG sites being critical for Polycomb recruitment, as shown in experiments with stem cells lacking DNA methyltransferase.